Center for Andrology and Division of Endocrinology, Medical Faculty Associates, The George Washington University, Washington, District of Columbia.
Alcohol Clin Exp Res. 2013 Nov;37(11):1823-6. doi: 10.1111/acer.12177. Epub 2013 Jun 13.
There is a robust literature in rodents, but not in humans, on the interaction between finasteride and alcohol, particularly as it relates to neurosteroids. Finasteride has been shown to reduce alcohol intake and suppress alcohol preference in male mice. This study examines the role of finasteride in alcohol consumption in humans with male pattern hair loss.
The subjects were 83 otherwise healthy men who developed persistent sexual side effects associated with finasteride, despite the cessation of this medication for at least 3 months. Information from standardized interviews was collected regarding medical histories, sexual function, and alcohol consumption before and after finasteride use.
Of the 63 men who consumed at least 1 alcoholic beverage/wk prior to starting finasteride, 41 (65%) noted a decrease in their alcohol consumption after stopping finasteride. This reduction typically began before discontinuing finasteride. Twenty men (32%) reported no change in their alcohol consumption, and 2 men (3%) reported an increase in their alcohol consumption. For the 63 consumers of alcohol, the mean number (± SE) of alcoholic beverages/wk declined from 5.2 ± 0.7 before finasteride to 2.0 ± 0.3 after finasteride (p < 0.0001). A major study limitation is the lack of a comparison group.
In former male users of finasteride who developed persistent sexual side effects, 65% noticed a decline in their alcohol consumption as compared to baseline. This finding is consistent with finasteride's ability to modulate alcohol intake in rodents. Further research is needed on the central nervous system effects of finasteride in humans.
在啮齿动物中，有大量关于非那雄胺和酒精相互作用的文献，但在人类中则没有，尤其是与神经甾体相关的内容。已证实非那雄胺可减少雄性小鼠的酒精摄入量并抑制其对酒精的偏好。本研究旨在探讨非那雄胺在患有男性型脱发的男性人群中对酒精摄入的作用。
受试者为 83 名健康男性，他们在停止使用非那雄胺至少 3 个月后仍出现与非那雄胺相关的持续性性功能障碍。通过标准化访谈收集了他们的病史、性功能和饮酒情况等信息。
在开始使用非那雄胺前每周至少饮用 1 次酒精饮料的 63 名男性中，有 41 名（65%）在停止使用非那雄胺后减少了酒精摄入量。这种减少通常在停止使用非那雄胺之前就开始了。20 名（32%）男性报告其酒精摄入量无变化，而 2 名（3%）男性报告其酒精摄入量增加。在 63 名饮酒者中，平均每周（± SE）酒精饮料数从使用非那雄胺前的 5.2 ± 0.7 下降至使用后的 2.0 ± 0.3（p < 0.0001）。主要研究局限性在于缺乏对照组。
在出现持续性性功能障碍的曾使用非那雄胺的男性中，与基线相比，有 65%的人注意到其酒精摄入量下降。这一发现与非那雄胺调节啮齿动物酒精摄入量的能力一致。需要进一步研究非那雄胺在人类中枢神经系统中的作用。
