Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Histopathology. 2013 Aug;63(2):208-16. doi: 10.1111/his.12168. Epub 2013 Jun 13.
To assess synaptophysin expression in columnar-lined oesophageal mucosa showing either goblet cells, known as intestinal metaplasia, or with accompanying oxyntic glands or pyloric glands.
Of 159 biopsies, 53 were oesophageal (19 had intestinal metaplasia, 13 oxyntic glands, and 21 pyloric glands), 77 gastric (12 had goblet cells and 27 no goblet cells) and 29 duodenal. Synaptophysin-positive goblet cells were found in all biopsies from the normal duodenum, in 53% of the oesophageal biopsies showing intestinal metaplasia, but only in 8% of gastric biopsies showing intestinal metaplasia. Synaptophysin-positive Paneth cells occurred in all duodenal biopsies, and in nine of the gastric biopsies showing intestinal metaplasia, but in only one of the oesophageal biopsies showing intestinal metaplasia. A continuous synaptophysin-positive neck cell zone was found in all biopsies from the normal antrum, but in none of the oesophageal biopsies with pyloric glands or with chronic antritis.
The paucity or absence of synaptophysin-positive cells in all three phenotypes of Barrett's mucosa might mirror a sequela of chronic inflammation caused by the particular pathogenic bacteria present in the immediate oesophageal microenvironment.
评估柱状上皮食管黏膜中突触素的表达情况，这些黏膜表现为杯状细胞，即肠化生，或伴有胃底腺或幽门腺。
在 159 例活检中，53 例为食管（19 例有肠化生，13 例有胃底腺，21 例有幽门腺），77 例为胃（12 例有杯状细胞，27 例无杯状细胞），29 例为十二指肠。所有来自正常十二指肠的活检均可见突触素阳性的杯状细胞，在 53%的有肠化生的食管活检中可见，但在仅有 8%的有肠化生的胃活检中可见。所有十二指肠活检均可见突触素阳性的 Paneth 细胞，在 9 例有肠化生的胃活检中可见，但在仅有 1 例有肠化生的食管活检中可见。在正常胃窦的所有活检中均可见连续的突触素阳性颈细胞区，但在有幽门腺或慢性胃炎的食管活检中均未见。
Barrett 黏膜的所有三种表型中突触素阳性细胞的缺乏或缺失可能反映了存在于食管微环境中的特定致病细菌引起的慢性炎症的后遗症。
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