韩国人所需的脐带血单位数量最少为 51,000。

The minimum number of cord blood units needed for Koreans is 51,000.

机构信息

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea.

出版信息

Transfusion. 2014 Mar;54(3):504-8. doi: 10.1111/trf.12284. Epub 2013 Jun 13.

DOI:10.1111/trf.12284

PMID:23763520

Abstract

BACKGROUND

The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity.

STUDY DESIGN AND METHODS

We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allogeneic hematopoietic stem cell transplantation. Two-digit HLA specificities were determined using intermediate DNA typing. From 17,508 stored Korean CBUs, 1460 haplotypes with a frequency greater than 0.001% were used for reconstitution of the HLA. A total of 1002 transplanted patients' HLA was used for matching probability calculation.

RESULTS

The best probability for 6/6 matching is 47% in 500,000 hypothetical size. Ninety-five percent probability is achieved with 51,000 CBUs in 5/6, and 2150 in 4/6 matching condition. Because 4/6 matched CB is rarely selected in the Korean situation, 51,000 units is the lowest limit of CBUs required and the number will be adjusted depending on the cell number required for patients and the resolution of HLA typing.

CONCLUSION

Approximately 51,000 units could provide the minimum requirement for hematopoietic transplantation in Korea.

摘要

背景

脐血（CB）的库存数量取决于人类白细胞抗原（HLA）的种族多样性，且对于每个种族的公共卫生而言，对其进行准确的数量估计非常重要。

研究设计与方法

我们对韩国储存的 CB 单位（CBU）和接受异基因造血干细胞移植的患者的 CB 库存数量进行了估计。使用中间 DNA 分型来确定两位数字 HLA 特异性。从 17508 份储存的韩国 CBU 中，使用频率大于 0.001%的 1460 种单倍型用于 HLA 的重建。总共使用了 1002 名移植患者的 HLA 进行匹配概率计算。

结果

在 50 万假设的 CBU 数量中，6/6 匹配的最佳概率为 47%。在 5/6 和 4/6 匹配条件下，95%的概率分别需要 51000 个和 2150 个 CBU 来实现。由于在韩国的情况下，4/6 匹配的 CB 很少被选择，因此 51000 个单位是韩国所需的 CBU 的最低下限，并且该数量将根据患者所需的细胞数量和 HLA 分型的分辨率进行调整。