State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.
Prog Mol Biol Transl Sci. 2013;118:413-27. doi: 10.1016/B978-0-12-394440-5.00016-4.
This review summarizes the regulatory roles of β-arrestins in whole-body energy balance, body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK signaling pathway being crucial for metabolic regulation. Furthermore, β-arrestins form diverse signal complexes for the activation of the downstream cassettes for the body's metabolic reactions. However, further studies are required to fully address the emerging roles of β-arrestins in metabolic regulation and related diseases.
这篇综述总结了β-arrestins 在全身能量平衡、体重控制以及碳水化合物和脂质动态平衡中的调节作用。大量研究表明，β-arrestins 在介导 G 蛋白偶联受体的脱敏和内吞作用以及激活受体/β-arrestin/ERK 信号通路方面发挥重要作用，该通路对于代谢调节至关重要。此外，β-arrestins 形成了多种信号复合物，用于激活体内代谢反应的下游级联。然而，需要进一步的研究来充分阐明β-arrestins 在代谢调节和相关疾病中的新兴作用。
