Siehr Stephanie L, Hanley Frank L, Reddy V Mohan, Miyake Christina Y, Dubin Anne M
Department of Pediatrics, Stanford University, Palo Alto, Calif, USA.
Congenit Heart Dis. 2014 May-Jun;9(3):211-5. doi: 10.1111/chd.12110. Epub 2013 Jun 14.
Complete atrioventricular block (AVB) is a recognized complication of ventricular septal defect (VSD) repair. The objective of this study was to examine incidence and risk factors.
This is a single-center, retrospective study. All pediatric patients (age <18 years) who underwent VSD repair between November 2001 and August 2009 with concordant atrioventricular and ventriculoarterial connections were included. Patients were classified as having no AVB or transient AVB, and outcomes of early pacemaker placement (before hospital discharge) or late pacemaker placement (after hospital discharge) were recorded.
Eight hundred twenty-eight patients (48.6% female) underwent VSD repair during the study period. Mean age at repair was 14 ± 29.4 months. A total of 64 patients (7.7%) developed surgical AVB. Among those patients who developed AVB, 48 (75%) had transient AVB. Sixteen patients (1.9%) required a pacemaker, 14 early (88%) and 2 late (12%). Patients <4 kg (4.2% vs. 1%, P ≤ .01) and those with inlet VSDs (11.6% vs. 1.4%, P ≤ .01) were more likely to develop surgical AVB. Surgical AVB was not influenced by the presence of chromosomal abnormalities or other congenital heart disease.
The overall incidence of surgical AVB is consistent with previous reports. Weight <4 kg and presence of an inlet VSD were significant risk factors.
完全性房室传导阻滞(AVB)是室间隔缺损(VSD)修复术后公认的并发症。本研究的目的是探讨其发生率及危险因素。
这是一项单中心回顾性研究。纳入2001年11月至2009年8月期间接受VSD修复术且房室和心室动脉连接一致的所有儿科患者(年龄<18岁)。患者分为无AVB或短暂性AVB,并记录早期起搏器植入(出院前)或晚期起搏器植入(出院后)的结果。
在研究期间,828例患者(48.6%为女性)接受了VSD修复术。修复时的平均年龄为14±29.4个月。共有64例患者(7.7%)发生手术性AVB。在发生AVB的患者中,48例(75%)为短暂性AVB。16例患者(1.9%)需要植入起搏器,14例为早期植入(88%),2例为晚期植入(12%)。体重<4kg的患者(4.2%对1%,P≤0.01)和流入道室间隔缺损患者(11.6%对1.4%,P≤0.01)更易发生手术性AVB。手术性AVB不受染色体异常或其他先天性心脏病的影响。
手术性AVB的总体发生率与既往报道一致。体重<4kg和存在流入道室间隔缺损是显著的危险因素。