通过优化扩散加权磁共振成像提高3特斯拉下缺血性病变的检测
Improving detection of ischemic lesions at 3 Tesla with optimized diffusion-weighted magnetic resonance imaging.
作者信息
Ract Isabelle, Ferré Jean-Christophe, Ronzière Thomas, Leray Emmanuelle, Carsin-Nicol Béatrice, Gauvrit Jean-Yves
机构信息
CHU Rennes, Department of Neuroradiology, hôpital Pontchaillou, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
CHU Rennes, Department of Neuroradiology, hôpital Pontchaillou, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.
出版信息
J Neuroradiol. 2014 Mar;41(1):45-51. doi: 10.1016/j.neurad.2013.04.003. Epub 2013 Jun 12.
BACKGROUND AND PURPOSE
This study compared three different combinations of DWI parameters: three and six diffusion imaging directions (3dir and 6dir, respectively) using b=1000 or 2000 s/mm(2) (b1000 or b2000, respectively) to improve detection of recent ischemic lesions at 3 Tesla (3 T).
MATERIALS AND METHODS
A total of 47 consecutive patients underwent three DWI scans: 3dir b1000; 6dir b1000; and 6dir b2000. Qualitative visual analysis was performed by three readers based on evaluation of the number of lesions, presence of artifacts and diagnostic confidence. Interobserver agreement, sensitivity, specificity, and positive and negative predictive values were calculated.
RESULTS
Forty-five lesions were detected by 3dir b1000, 52 by 6dir b1000 and 56 by 6dir b2000 in 30 patients. The additional lesions identified by 6dir b2000 were either small or located in the posterior fossa. Sensitivity with 6dir b2000 was significantly higher than with 3dir b1000 (98.1% vs 77.4%; P<0.05).
CONCLUSION
At 3 T, 6dir b2000 DWI detected more acute ischemic lesions than 3dir b1000, particularly small lesions and those located in the brain stem.
背景与目的
本研究比较了三种不同的扩散加权成像（DWI）参数组合：分别使用b值为1000或2000 s/mm²（分别为b1000或b2000）的三个和六个扩散成像方向（分别为3dir和6dir），以提高在3特斯拉（3T）磁场下对近期缺血性病变的检测能力。
材料与方法
共有47例连续患者接受了三次DWI扫描：3dir b1000；6dir b1000；以及6dir b2000。由三位阅片者基于对病变数量、伪影的存在情况以及诊断信心的评估进行定性视觉分析。计算观察者间一致性、敏感性、特异性以及阳性和阴性预测值。
结果
在30例患者中，3dir b1000检测到45个病变，6dir b1000检测到52个病变，6dir b2000检测到56个病变。6dir b2000识别出的额外病变要么较小，要么位于后颅窝。6dir b2000的敏感性显著高于3dir b1000（98.1%对77.4%；P<0.05）。
结论
在3T磁场下，6dir b2000 DWI比3dir b1000能检测到更多的急性缺血性病变，尤其是小病变和位于脑干的病变。
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