Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Trop Pediatr. 2013 Oct;59(5):423-5. doi: 10.1093/tropej/fmt043. Epub 2013 Jun 13.
Japanese encephalitis virus is a common cause of encephalitis in Asian children; therefore, maintenance of immunity against Japanese encephalitis virus is essential. Although many countries recommend booster vaccination, some trials have concluded that administration of one or two vaccinations is sufficient. The current study was conducted to evaluate immunogenicity and safety after a booster vaccination with live attenuated vaccine. For 68 study subjects, measurement of antibody titer was performed before and at 4-6 weeks after administration of a booster dose. Adverse reactions occurring at the injection site and systemic adverse reactions were documented. The percentages of subjects with seroprotective neutralizing antibody titers was 100% before and after booster vaccination, and the geometric mean titer increased after booster vaccination. Thus, we predict that immunity will be maintained for a long time by an amnestic response. Low percentages of adverse reactions indicated the safety of the immunizations.
日本脑炎病毒是亚洲儿童脑炎的常见病因；因此，保持对日本脑炎病毒的免疫力至关重要。尽管许多国家建议加强疫苗接种，但一些试验得出的结论是，接种一剂或两剂疫苗就足够了。本研究旨在评估用减毒活疫苗进行加强免疫后的免疫原性和安全性。对 68 名研究对象在接种加强剂量前后 4-6 周进行抗体滴度测量。记录注射部位和全身不良反应的发生情况。接种加强针前后，具有血清保护性中和抗体滴度的受试者百分比均为 100%，且加强针接种后几何平均滴度增加。因此，我们预测通过记忆应答将长期维持免疫力。不良反应的低发生率表明免疫接种的安全性。
