Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Eur Arch Otorhinolaryngol. 2013 Sep;270(9):2569-73. doi: 10.1007/s00405-013-2595-9. Epub 2013 Jun 14.
Decreased volume of gray matter (GM) was observed in olfactory loss in patients with neurodegenerative disorder. However, GM volume has not yet been investigated in isolated congenital anosmia (ICA) people. We herewith investigated the volume change of gray matter of an ICA boy by morphometric analysis of magnetic resonance images (voxel-based morphometry), and compared with that of 20 age-matched healthy controls. ICA boy presented a significant decrease in GM volume in the orbitofrontal cortex, anterior cingulate cortex, middle cingulate cortex, thalamus, insular cortex, cerebellum, precuneus, gyrus rectus, subcallosal gyrus, middle temporal gyrus, fusiform gyrus and piriform cortex. No significant GM volume increase was detected in other brain areas. The pattern of GM atrophy was similar as previous literature reported. Our results identified similar GM volume alterations regardless of the causes of olfactory impairment. Decreased GM volume was not only shown in olfactory bulbs, olfactory tracts and olfactory sulcus, also in primary olfactory cortex and the secondary cerebral olfactory areas in ICA people. This is the first study to evaluate GM volume alterations in ICA people.
在神经退行性疾病患者的嗅觉丧失中，观察到灰质（GM）体积减少。然而，孤立性先天性嗅觉缺失（ICA）人群的 GM 体积尚未得到研究。我们通过磁共振成像的形态计量分析（体素形态计量学法）对一位 ICA 男孩的灰质体积变化进行了研究，并与 20 名年龄匹配的健康对照者进行了比较。ICA 男孩的眶额皮质、前扣带皮质、中扣带皮质、丘脑、岛叶皮质、小脑、楔前叶、直回、胼胝体下区、颞中回、梭状回和梨状皮质的 GM 体积明显减少。在其他脑区未发现 GM 体积的显著增加。GM 萎缩的模式与之前的文献报道相似。我们的结果表明，无论嗅觉损伤的原因如何，GM 体积的改变都是相似的。GM 体积减少不仅表现在嗅球、嗅束和嗅沟，也表现在 ICA 患者的初级嗅觉皮质和次级大脑嗅觉区。这是首次评估 ICA 患者 GM 体积改变的研究。
