Kim Won Joong, Kang Hyun, Shin Hwa Yong, Baek Chong Wha, Jung Yong Hun, Woo Young Cheol, Kim Jin Yun, Koo Gil Hoi
Department of Anaesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
J Int Med Res. 2013 Aug;41(4):1203-13. doi: 10.1177/0300060513485864. Epub 2013 Jun 13.
To compare the efficacy of ramosetron, midazolam, and the combination of ramosetron and midazolam in the prevention of postoperative nausea and vomiting (PONV) in female patients undergoing thyroidectomy.
Patients were randomized to receive 0.3 mg ramosetron (Group R), 75 µg/kg midazolam (Group M) or 0.3 mg ramosetron combined with 75 µg/kg midazolam (Group RM) before the induction of anaesthesia. PONV, use of rescue antiemetics, pain severity and fentanyl consumption were assessed for 24 h after thyroidectomy.
A total of 100 patients were enrolled; 94 patients completed the study. The severity of nausea was statistically significantly reduced at 0-2 h in Group RM compared with Groups R and M, and at 2-6 h in Group RM compared with Group M. The incidence of retching and vomiting was significantly lower at 0-2 h, 2-6 h, 6-12 h in Group RM than in Group M, and lower in Group R than Group M at 6-12 h. The requirement for rescue antiemetics was significantly lower at 0-2 h in group RM than in group M.
The combination therapy of ramosetron and midazolam provided superior antiemetic efficacy compared with midazolam single therapy, but did not show any significant additional benefits compared with ramosetron single therapy.
比较雷莫司琼、咪达唑仑以及雷莫司琼与咪达唑仑联合用药在预防甲状腺切除术女性患者术后恶心呕吐（PONV）方面的疗效。
患者在麻醉诱导前被随机分为三组，分别接受0.3毫克雷莫司琼（R组）、75微克/千克咪达唑仑（M组）或0.3毫克雷莫司琼联合75微克/千克咪达唑仑（RM组）。在甲状腺切除术后24小时内评估PONV、抢救性止吐药的使用、疼痛严重程度和芬太尼用量。
共纳入100例患者；94例患者完成研究。RM组在0 - 2小时时恶心严重程度与R组和M组相比有统计学显著降低，在2 - 6小时时RM组与M组相比有统计学显著降低。RM组在0 - 2小时、2 - 6小时、6 - 12小时时干呕和呕吐发生率显著低于M组，在6 - 12小时时R组低于M组。RM组在0 - 2小时时对抢救性止吐药的需求显著低于M组。
与咪达唑仑单一疗法相比，雷莫司琼与咪达唑仑联合疗法具有更好的止吐效果，但与雷莫司琼单一疗法相比未显示出任何显著的额外益处。
