Forget P, Coulie P G, Retsky M, Demicheli R, Machiels J P, De Kock M
Department of Anesthesiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Acta Anaesthesiol Belg. 2013;64(1):15-24.
Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
肿瘤生长在围手术期可能会加速。因此，一些患者在术后的头两年内会出现癌症早期复发。对癌症病理生理学的时间和生物学分析表明，围手术期的病理生理变化与肿瘤生长加速之间存在联系。了解炎症的作用及其后果（即免疫反应、生长因子、肿瘤细胞播散）可能有助于明确麻醉医生在降低术后癌症复发方面的作用。我们主张进行围手术期药物干预以减少癌症复发，重点是使用非甾体类抗炎药。
