Sullivan R E, Miller M W
Békésy Laboratory of Neurobiology, University of Hawaii, Honolulu 96822.
J Neurobiol. 1990 Jun;21(4):639-50. doi: 10.1002/neu.480210411.
The frequency of rhythmic burst activity of the isolated lobster cardiac ganglion is increased by exogenously applied acetylcholine and muscarinic agonists. Responses of individual motor neurons isolated from the ganglion by transection consist of a slow depolarization and repetitive bursting. The pharmacological profile of the receptors mediating this response is similar to that of vertebrate neuronal muscarinic receptors. Isolated ganglia incubated in the presence of [3H]-choline (18-19 h) exhibited radiolabelled acetylcholine accumulation. It is suggested that ganglionic excitation may be accomplished by extrinsic or intrinsic activation of muscarinic receptors on the motor neurons.
外源性应用乙酰胆碱和毒蕈碱激动剂可增加离体龙虾心脏神经节的节律性爆发活动频率。通过横切从神经节分离出的单个运动神经元的反应包括缓慢去极化和重复爆发。介导这种反应的受体的药理学特征与脊椎动物神经元毒蕈碱受体相似。在[3H]-胆碱存在下孵育（18 - 19小时）的离体神经节表现出放射性标记的乙酰胆碱积累。提示神经节兴奋可能通过运动神经元上毒蕈碱受体的外在或内在激活来实现。
