Fernández González Francisco, Betancourt José, Malpica Juan C, Laboy Iván, Colón Miguel
Internal Medicine Department, San Juan City Hospital, CMMS #79 P.O. Box 70344, San Juan, Puerto Rico 00936-8344.
Bol Asoc Med P R. 2013;105(1):48-50.
Herpes simplex virus (HSV) is a host-adapted human pathogen. HSV-I usually infects non-genital sites at a variety of locations. HSV-2 primarily involves genitalia. Both types can cause genital and orofacial infections, which are clinically indistinguishable. Initial HSV infection is usually asymptomatic or mild and self-limited, but instead of disappearing from the body during convalescence, the virus establishes a latent infection that persists for life. Rarely, there is severe visceral dissemination. This is a case report of an unusual presentation of herpes simplex in an immunocompromised adult patient with generalized skin lesions on the entire body. To our knowledge, this is the first case reported in the literature of a disseminated herpes simplex in a patient with history of non-Hodgkin Lymphoma. Generalized HSV infection in immunodeficient adult patients could be fatal in spite of antiviral therapy. Early recognition of this entity is essential to expedite appropriate treatment and avoid future complications.
单纯疱疹病毒（HSV）是一种适应宿主的人类病原体。HSV-1通常感染身体各个部位的非生殖器部位。HSV-2主要累及生殖器。两种类型均可引起生殖器和口面部感染，临床上难以区分。初次HSV感染通常无症状或症状轻微且具有自限性，但病毒并非在恢复期从体内消失，而是建立潜伏感染并终生持续存在。极少数情况下，会出现严重的内脏播散。本文报告了一例免疫功能低下的成年患者全身出现广泛性皮肤损害的单纯疱疹不寻常表现。据我们所知，这是文献中首例有非霍奇金淋巴瘤病史患者发生播散性单纯疱疹的病例报告。尽管进行了抗病毒治疗，免疫功能低下的成年患者发生广泛性HSV感染仍可能致命。早期识别该疾病对于加快适当治疗并避免未来并发症至关重要。
