Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100 Tandogan-Ankara, Turkey.
Pharm Biol. 2013 Aug;51(8):1008-13. doi: 10.3109/13880209.2013.774028. Epub 2013 Jun 14.
Liverworts (Marchantiophyta) are the second largest group of bryophytes exhibiting promising pharmacological and biological activities. They have been used as remedies for cuts, fractures, burns, bruises, open wounds, inflammation and pneumonia.
In the present study, eight liverwort species [Corsinia coriandrina (Spreng.) Lindb. (Corsiniaceae), Mannia androgyna (L.) A. Evans (Aytoniaceae), Plagiochasma rupestre (J.R. Forst et G. Forst) Steph. (Aytoniaceae), Porella cordaeana (Huebener) Moore (Porellaceae), Porella platyphylla (L.) Pfeiff. (Porellaceae), Reboulia hemisphaerica (L.) Raddi (Aytoniaceae), Riccia fluitans L. (Ricciaceae), and Targionia hypophylla L. (Targioniaceae)] have been investigated for their phytochemical composition and pharmacological effects as a function of anti-inflammatory and antinociceptive potentials, in connection with the major volatile components of the extracts.
The chemical compositions of these species and major constituents were identified using GC/MS. In addition, carrageenan-induced paw edema and p-benzoquinone-induced abdominal constriction models were used for the activity assessments.
Sesquiterpenes were detected as common constituents of all liverworts. The in vivo experimental models revealed that P. cordeana, P. rupestre and R. haemispherica show significant inhibitory effect on carrageenan-induced paw edema with the inhibition values of 25.4, 27.2 and 29.4%, respectively. Porella cordaeana, P. platyphylla, P. rupestre and R. haemispherica exhibit promising suppressing effect on p-benzoquinone-induced abdominal constriction animal models with the values of 27.6, 31.5, 44.6, and 41.1%, respectively.
It is suggested that the sesquiterpenes are partly responsible for mentioned activities of the liverworts.
The present study confirms the claimed anti-inflammatory activity of liverworts in a scientific platform.
地钱植物门（Marchantiophyta）是苔藓植物门中第二大的类群，具有有前景的药理学和生物学活性。它们被用作治疗伤口、骨折、烧伤、瘀伤、开放性伤口、炎症和肺炎的药物。
在本研究中，对八种地钱植物物种[地钱科（Corsinia coriandrina (Spreng.) Lindb.）、真藓科（Mannia androgyna (L.) A. Evans）、真藓科（Plagiochasma rupestre (J.R. Forst et G. Forst) Steph.）、瘤冠苔科（Porella cordaeana (Huebener) Moore）、瘤冠苔科（Porella platyphylla (L.) Pfeiff.）、真藓科（Reboulia hemisphaerica (L.) Raddi）、溪苔科（Riccia fluitans L.）和溪苔科（Targionia hypophylla L.）]进行了植物化学组成和药理作用的研究，作为抗炎和镇痛潜力的功能，与提取物的主要挥发性成分有关。
使用 GC/MS 鉴定这些物种和主要成分的化学组成。此外，还使用角叉菜胶诱导的足肿胀和 p-苯醌诱导的腹部收缩模型进行活性评估。
倍半萜被检测为所有地钱植物的常见成分。体内实验模型表明，瘤冠苔、地钱和真藓科表现出对角叉菜胶诱导的足肿胀的显著抑制作用，抑制率分别为 25.4%、27.2%和 29.4%。瘤冠苔、地钱、瘤冠苔和真藓科对 p-苯醌诱导的腹部收缩动物模型具有显著的抑制作用，抑制率分别为 27.6%、31.5%、44.6%和 41.1%。
认为倍半萜类化合物部分负责地钱植物的上述活性。
本研究在科学平台上证实了地钱抗炎活性的说法。
