Hebei Province Center for Disease Prevention and Control, No. 97, Huai'an Donglu, Shijiazhuang City, Hebei Province 050021, People's Republic of China.
Hengshui Municipal Center for Disease Control and Prevention, Hengshui City, Hebei Province, People's Republic of China.
Br J Nutr. 2014 Jan 14;111(1):86-92. doi: 10.1017/S0007114513001906. Epub 2013 Jun 17.
The prevalence of goitre in areas with mildly excessive iodine in drinking-water is still under debate. The aim of the present study was to explore the prevalence of goitre and its epidemiological characteristics in these areas using WHO criteria. To this end, three towns with a median water iodine (MWI) of 150-300 μg/l were selected randomly in Hengshui City of Hebei Province of China, and one town with a MWI of 105 μg/l was chosen as a control. A total of 452 children in the three towns and 120 children in the control town were randomly selected to measure thyroid volume (T vol) by ultrasound. The goitre status of these children was judged using the criteria recommended by the WHO. The overall goitre prevalences in the three towns were 24·6 % (111/452) by age-specific T vol and 33·0 % (149/452) by body surface area (BSA)-adjusted T vol, which were significantly higher than that in the control town by both age-specific T vol (14·0 % (17/120), P= 0·015) and BSA-adjusted T vol (17·5 % (21/120), P= 0·001). Significant differences were found neither in goitre prevalences across sex by both age-specific T vol (P= 0·078) and BSA-adjusted T vol (P= 0·692) nor in that across age group by both BSA-adjusted T vol (P= 0·461) and age-specific T vol (P= 0·183). The present study found a high prevalence of goitre in children living in areas with mildly excessive iodine in drinking-water in Hebei Province. No significant differences were found in goitre prevalences across sex and age group. These results suggest that the T vol reference values recommended by the WHO could be too low for Chinese children.
在饮用水碘含量轻度超标的地区，甲状腺肿的患病率仍存在争议。本研究旨在使用世界卫生组织（WHO）标准，探讨这些地区甲状腺肿的患病率及其流行病学特征。为此，在中国河北省衡水市随机选择了 3 个水碘中位数（MWI）为 150-300μg/L 的城镇，以及 1 个 MWI 为 105μg/L 的城镇作为对照。随机选择这 3 个城镇的 452 名儿童和对照城镇的 120 名儿童，用超声测量甲状腺容积（Tvol）。根据 WHO 推荐的标准判断这些儿童的甲状腺肿状况。按年龄特异性 Tvol 计算，3 个城镇的总甲状腺肿患病率为 24.6%（111/452），按体表面积（BSA）校正的 Tvol 计算，总甲状腺肿患病率为 33.0%（149/452），均显著高于对照城镇的年龄特异性 Tvol（14.0%（17/120），P=0.015）和 BSA 校正的 Tvol（17.5%（21/120），P=0.001）。按年龄特异性 Tvol（P=0.078）和 BSA 校正的 Tvol（P=0.692），性别间甲状腺肿患病率无显著差异，按 BSA 校正的 Tvol（P=0.461）和年龄特异性 Tvol（P=0.183），年龄组间甲状腺肿患病率亦无显著差异。本研究发现，河北省饮用水碘含量轻度超标的地区儿童甲状腺肿患病率较高。性别和年龄组间甲状腺肿患病率无显著差异。这些结果提示，WHO 推荐的 Tvol 参考值可能对中国儿童过低。
