Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02130, USA.
Behav Ther. 2013 Sep;44(3):432-42. doi: 10.1016/j.beth.2013.03.008. Epub 2013 Apr 6.
The present study sought to extend prior work, showing an association between self-reported distress tolerance and self-reported antiretroviral treatment (ART) adherence, by conducting a multimethod test of the association between distress tolerance and objective measures of ART adherence among a sample of 140 individuals (23.6% female) with human immunodeficiency virus (HIV). Findings indicated that, after accounting for negative affectivity and ART side-effect severity, distress tolerance was significantly associated with pill count adherence as well as viral load. Specifically, a differential association was observed whereby self-reported distress tolerance was associated with pill count adherence, whereas behavioral distress tolerance was associated with viral load. Importantly, no associations were observed between either measure of distress tolerance and CD4 count. Findings are discussed in terms of the importance of both behavioral and perceived distress tolerance assessment among patients with HIV as well as potential clinical implications related to the integration of distress tolerance-focused treatments into existing interventions for individuals with HIV.
本研究旨在通过对 140 名人类免疫缺陷病毒 (HIV) 感染者（23.6%为女性）的样本进行多项方法检验，扩展先前关于报告的痛苦耐受力与报告的抗逆转录病毒治疗 (ART) 坚持之间的关联的研究，以评估痛苦耐受力与客观的 ART 坚持测量之间的关联。研究结果表明，在考虑到负性情感和 ART 副作用严重程度后，痛苦耐受力与药物计数坚持以及病毒载量显著相关。具体而言，观察到了一种差异关联，即自我报告的痛苦耐受力与药物计数坚持相关，而行为痛苦耐受力与病毒载量相关。重要的是，两种痛苦耐受力测量方法均与 CD4 计数之间没有关联。研究结果讨论了在 HIV 患者中评估行为和感知痛苦耐受力的重要性，以及将以痛苦耐受力为重点的治疗方法整合到针对 HIV 感染者的现有干预措施中的潜在临床意义。
