Neuroimmunology and Neuromuscular Disorders Unit, Foundation IRCCS Neurological Institute C. Besta, Via Celoria 11, 20133 Milan, Italy.
J Neuroimmunol. 2013 Sep 15;262(1-2):19-26. doi: 10.1016/j.jneuroim.2013.05.010. Epub 2013 Jun 13.
The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient's IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient's IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS.
抗体在多发性硬化症(MS)中的致病作用仍存在争议。我们将一位 MS 患者在选择性免疫球蛋白去除免疫吸附后复发期间出现显著临床改善时所产生的 IgG 抗体转移到实验性自身免疫性脑脊髓炎(EAE)小鼠,即 MS 的动物模型中。患者 IgG 的被动转移加剧了运动瘫痪,并增加了小鼠中枢神经系统(CNS)炎症和脱髓鞘。在小鼠中枢神经系统中检测到患者 IgG 的结合,伴有白质少突胶质细胞弥漫性染色。这些数据支持越来越多的证据表明,抗体在 MS 的病理生物学中可能发挥重要作用。