Sakakibara T, Kaneko E, Kumagai J, Ito G, Ooi S
First Department of Medicine, Hamamatsu University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1990 Apr;87(4):951-6.
Patients with duodenal ulcer were classified into responders to H2-receptor antagonist and non-responders in whom duodenal ulcer did not heal within three months with the antagonist. In these patients and healthy controls, modified sham-feeding (MSF) test was performed to elucidate the pathophysiological differences between these groups, especially vagal activity of acid output. After tetragastrin 4 micrograms/kg/hr infusion for one hour, MSF was superimposed to the infusion (G + MSF). The acid output of non-responders (8 cases) and controls (8 cases) significantly increased in G + MSF. On the other hand, the acid output of responders (6 cases) significantly decreased. The acid output of non-responders in G + MSF was also significantly higher than that of controls. The results suggest that vagal activity of non-responders is higher than responders, and that there is disturbance of inhibitory mechanism in vagal system.
十二指肠溃疡患者被分为对H2受体拮抗剂有反应者和无反应者，后者使用该拮抗剂治疗三个月内十二指肠溃疡未愈合。在这些患者和健康对照者中，进行了改良假饲（MSF）试验，以阐明这些组之间的病理生理差异，尤其是胃酸分泌的迷走神经活动。在以4微克/千克/小时的速度输注四肽胃泌素1小时后，将MSF叠加于输注过程中（G + MSF）。无反应者（8例）和对照者（8例）的胃酸分泌在G + MSF时显著增加。另一方面，有反应者（6例）的胃酸分泌显著减少。G + MSF时无反应者的胃酸分泌也显著高于对照者。结果表明，无反应者的迷走神经活动高于有反应者，且迷走神经系统存在抑制机制紊乱。
