妊娠中期因意外过量服用对乙酰氨基酚导致肝移植：一例病例报告

Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report.

作者信息

Franko K R, Mekeel K L, Woelkers D, Khanna A, Hemming A W

机构信息

Department of Transplant and Hepatobiliary Surgery, University of California at San Diego, CA 92103, USA.

出版信息

Transplant Proc. 2013 Jun;45(5):2063-5. doi: 10.1016/j.transproceed.2012.10.046.

DOI:10.1016/j.transproceed.2012.10.046

PMID:23769109

Abstract

Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries. Pregnant women are counseled that acetaminophen is safe during pregnancy and an alternative to nonsteroidal anti-inflammatory medications. This report describes a case of acetaminophen overdose during the second trimester of pregnancy with resultant fulminant hepatic failure requiring liver transplantation. The fetus was previable at the time of liver transplantation, and methods to preserve viability during and after transplantation are discussed. Despite the best attempts of the team, the fetus expired. The challenges and outcomes of fulminant hepatic failure in pregnancy are discussed in detail.

摘要

对乙酰氨基酚过量是西方国家暴发性肝衰竭最迅速增长的病因。孕妇被告知对乙酰氨基酚在孕期是安全的，可作为非甾体类抗炎药的替代品。本报告描述了一例孕中期对乙酰氨基酚过量导致暴发性肝衰竭并需要肝移植的病例。肝移植时胎儿未达可存活状态，并讨论了在移植期间及之后维持胎儿存活的方法。尽管团队尽了最大努力，胎儿仍死亡。详细讨论了妊娠合并暴发性肝衰竭的挑战和结局。