Tamaki N, Yonekura Y, Magata Y, Saji H, Fujibayashi Y, Sasayama S, Yamashita K, Ohtani H, Fujita T, Yamada T
Department of Radiology and Nuclear Medicine, Kyoto University Faculty of Medicine.
Kaku Igaku. 1990 Apr;27(4):313-21.
Serial dynamic images were obtained at rest following intravenous injection of 185-370 MBq (5-10 mCi) of 11C-palmitate for 40-50 minutes in 3 normal subjects and 6 patients with coronary artery disease. Due to the rapid clearance of activity from the blood, myocardial images were observed within 5 minutes after the injection in each case. The time activity curve of each myocardial region indicates biexponential clearance. The early clearance half time (Te 1/2) was similar in normal myocardium (18.8 +/- 6.0 min), ischemic myocardium (19.3 +/- 5.8 min) and infarcted myocardium (15.5 +/- 6.0 min). The late clearance half time (Tl 1/2) was also similar among these groups (81.4 +/- 36.0, 66.9 +/- 25.7 and 57.8 +/- 37.4, respectively). However, the residual fraction (%E) was slightly lower in the ischemic myocardium (19.6 +/- 11.0%) (p less than 0.05), indicating decreased beta oxidation in the former. Although positron emission tomography using 11C-palmitate may permit assessment of fatty acid metabolism, the parameters in this study were greatly fluctuated at rest among the normal, ischemic and infarcted myocardium. Further investigations under various interventions may be warranted.
在3名正常受试者和6名冠心病患者静脉注射185 - 370 MBq（5 - 10 mCi）的11C - 棕榈酸盐后，静息状态下获得系列动态图像。由于血液中放射性活性的快速清除，在每种情况下注射后5分钟内即可观察到心肌图像。每个心肌区域的时间 - 活性曲线显示双指数清除。正常心肌（18.8±6.0分钟）、缺血心肌（19.3±5.8分钟）和梗死心肌（15.5±6.0分钟）的早期清除半衰期（Te 1/2）相似。这些组之间的晚期清除半衰期（Tl 1/2）也相似（分别为81.4±36.0、66.9±25.7和57.8±37.4）。然而，缺血心肌中的残留分数（%E）略低（19.6±11.0%）（p＜0.05），表明前者的β氧化减少。尽管使用11C - 棕榈酸盐的正电子发射断层扫描可能允许评估脂肪酸代谢，但本研究中的参数在正常、缺血和梗死心肌的静息状态下波动很大。可能需要在各种干预措施下进行进一步研究。
