Takeishi Y, Tono-Oka I, Meguro M, Hoshi H, Masakane I, Chiba J, Abe S, Komatani A, Takahashi K, Tsuiki K
First Department of Internal Medicine, Yamagata University School of Medicine.
Kaku Igaku. 1990 Apr;27(4):373-8.
Thallium-201 myocardial perfusion imaging with dipyridamole was performed on 78 patients (pts) with suspected coronary artery disease (CAD). Twenty eight pts had normal coronary arteries (control group), and 50 pts had 50% or greater stenosis in one or more major coronary arteries (CAD group). In control group, aminophylline (Am) was infused intravenously on 12 pts during dipyridamole testing. Mean washout rate (WR) of these 12 pts was greater than that of 16 pts without Am (42% vs 35%, p less than 0.01). Then normal limit of WR was defined separately from the pts of control group with and without Am. The sensitivity for detecting the pts with CAD by WR analysis which normal limit was calculated separately with and without Am was 92% (46/50). When normal limit of WR was determined from all pts in control group, the sensitivity decreased to 84% (42/50). Am significantly affected thallium-201 washout during dipyridamole testing. WR of CAD pts should be estimated by specific set of normal limit with and without Am.
对78例疑似冠心病（CAD）患者进行了双嘧达莫负荷铊-201心肌灌注显像。28例患者冠状动脉正常（对照组），50例患者一支或多支主要冠状动脉存在50%或以上狭窄（CAD组）。对照组中，12例患者在双嘧达莫试验期间静脉输注氨茶碱（Am）。这12例患者的平均洗脱率（WR）高于16例未使用Am的患者（42%对35%，p<0.01）。然后分别根据使用和未使用Am的对照组患者确定WR的正常范围。通过分别使用和未使用Am计算正常范围的WR分析检测CAD患者的敏感性为92%（46/50）。当根据对照组所有患者确定WR的正常范围时，敏感性降至84%（42/50）。Am在双嘧达莫试验期间显著影响铊-201的洗脱。CAD患者的WR应通过使用和未使用Am的特定正常范围集来估计。
