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[直肠癌与特鲁索综合征。病例报告]

[Rectal cancer and Trousseau syndrome. Case report].

作者信息

Sierra-Montenegro Ernesto, Sierra-Luzuriaga Gastón, Calle-Loffredo Daniel, Rodríguez Quinde Miguel

机构信息

Servicio de Coloproctología, Hospital Teodoro Maldonado Carbo, Guayaquil, Ecuador.

出版信息

Cir Cir. 2013 May-Jun;81(3):242-5.

PMID:23769256
Abstract

BACKGROUND

The Trousseau syndrome, first described in 1865, is the relationship of venous thromboembolisms and cancer. We present a case with rectal cancer and Trousseau syndrome.

CLINICAL CASE

Female 40 years old, went to the Coloproctology Service for painless bleeding. A computed tomography report showed a tumor of 5 by 6 cm up 5 cm from the anal margin. Ultra-low anterior resection with colonic reservoir and loop ileostomy surgery was performed. The pathology report showed a semidiferenciate adenocarcinoma of the rectum and we established the stage as T3N0M0. Within 72 hours of her operation, she experienced sudden hypotension and painful abdominal distention. A second surgery was done finding necrosis of the colon from the splenic angle until the colonic reservoir with thrombi in the left colic artery, ischemic signs of bilateral fallopian tubes, ovaries, uterus, pelvic floor and the small intestine, 40 cm before ileostomy and ileon. Left hemicolectomy and colostomy was done. She was taken to intensive care where continuous administration of heparin was given; she died within 5 days because of multiorgan failure.

CONCLUSIONS

The mechanism for this syndrome was unknown but there are several hypotheses, suggesting that hematological cancer patients are at an increased risk of deep vein thrombosis. Pancreatic cancer is the most common presentation with this syndrome (in 50% of cases). We suggested continuing with the standards of prevention of thromboembolism.

摘要

背景

特鲁索综合征于1865年首次被描述,是静脉血栓栓塞与癌症之间的关系。我们报告一例直肠癌合并特鲁索综合征的病例。

临床病例

一名40岁女性,因无痛性出血前往结直肠外科就诊。计算机断层扫描报告显示,距肛门边缘5厘米处有一个5×6厘米的肿瘤。行低位前切除术、结肠贮袋成形术及回肠袢式造口术。病理报告显示为直肠半分化腺癌,分期为T3N0M0。术后72小时内,她突然出现低血压和腹部胀痛。再次手术发现,从脾曲到结肠贮袋的结肠坏死,左结肠动脉有血栓形成,双侧输卵管、卵巢、子宫、盆底和小肠有缺血迹象,回肠造口和回肠前40厘米处也有缺血迹象。行左半结肠切除术和结肠造口术。她被送往重症监护室,持续给予肝素治疗;5天内死于多器官功能衰竭。

结论

该综合征的发病机制尚不清楚,但有几种假说,提示血液系统癌症患者深静脉血栓形成的风险增加。胰腺癌是该综合征最常见的表现形式(50%的病例)。我们建议继续遵循血栓栓塞的预防标准。

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