Service de pharmacologie clinique, hôpital Sud, CHU d'Amiens, avenue René-Laennec, Salouel, 80054 Amiens cedex 1, France.
Arch Cardiovasc Dis. 2013 May;106(5):333-9. doi: 10.1016/j.acvd.2013.02.003. Epub 2013 Mar 22.
Numerous reports have shown an unquestionable association between fibrotic valve disease and the following drugs: ergot alkaloids (such as methysergide and ergotamine), ergot-derived dopaminergic agonists (such as pergolide and cabergoline) and drugs metabolized into norfenfluramine (such as fenfluramine, dexfenfluramine and benfluorex). This review focuses on different aspects of drug-induced valvular heart disease: historical background; echocardiographic features; different drugs recognized as being responsible for valvular heart disease; and pathophysiology.
大量报告表明，纤维性瓣膜病与以下药物之间存在明确的关联：麦角生物碱（如麦角乙脲和麦角胺）、麦角衍生的多巴胺激动剂（如培高利特和卡麦角林）以及代谢为 norfenfluramine 的药物（如芬氟拉明、右芬氟拉明和苯氟雷司）。这篇综述重点介绍了药物性心脏瓣膜病的不同方面：历史背景；超声心动图特征；被认为可引起心脏瓣膜病的不同药物；以及病理生理学。
