羟丙基甲基纤维素（HPMC）在兔眼前房的生物相容性和药代动力学
[Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].
作者信息
Ehrich W, Höh H, Kreiner C F
机构信息
Augenklinik der Universität des Saarlandes, Homburg/Saar.
出版信息
Klin Monbl Augenheilkd. 1990 Jun;196(6):470-4. doi: 10.1055/s-2008-1046226.
PMID:2376944
Abstract
The biocompatibility and pharmacokinetics of hydroxypropylmethylcellulose (HPMC) 2% (Adatocel) and Tylose 2% (MH 1000) were investigated. A modified anterior chamber implantation test on the rabbit eye is suitable for testing both the biocompatibility and the pharmacokinetics of visco-surgical substances. Both substances were well tolerated. From the fourth day onward, HPMC was no longer detectable in the anterior chamber by infrared spectroscopy.
摘要
对2%羟丙基甲基纤维素（Adatocel）和2%泰勒糖（MH 1000）的生物相容性和药代动力学进行了研究。改良的兔眼前房植入试验适用于测试粘弹手术物质的生物相容性和药代动力学。两种物质耐受性良好。从第四天起，通过红外光谱在前房中不再检测到羟丙基甲基纤维素。
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