Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Chin Med J (Engl). 2013;126(11):2129-33.
To evaluate the safety of intracytoplasmic sperm injection (ICSI) with epididymal or testicular sperm, this study compared children born after ICSI treatment with epididymal or testicular sperm with children conceived after ICSI with ejaculated sperm.
This retrospective study included 317 children born after ICSI with percutaneous epididymal sperm aspiration (PESA), 103 children born after ICSI with testicular sperm aspiration (TESA), and a control group of 1008 children born after ICSI with ejaculated sperm. All of the patients received their assisted reproductive treatment in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2004 to December 2011. Data, such as the rate of stillbirths, perinatal mortality, gestational age, birth weight, and the rate of congenital malformations of the three groups, were compared.
PESA and TESA children were not different from ICSI children in the rate of stillbirths, perinatal mortality, infant mortality rate, gestational age, the rate of prematurity, and the rate of malformations (P > 0.05). A slight increase in birth defects was reported in the TESA group compared with those in the control group, but there was no significant difference between the groups (P > 0.05).
ICSI with epididymal or testicular sperm does not lead to more stillbirths or congenital malformations compared with ICSI using ejaculated sperm.
为了评估卵胞浆内单精子注射（ICSI）中使用附睾或睾丸精子的安全性，本研究比较了经皮附睾精子抽吸术（PESA）或睾丸精子抽吸术（TESA）后行 ICSI 出生的儿童与射出精液后行 ICSI 出生的儿童。
本回顾性研究纳入了 2004 年 1 月至 2011 年 12 月期间在郑州大学第一附属医院生殖医学中心接受治疗的 317 名经 PESA 后行 ICSI 出生的儿童、103 名经 TESA 后行 ICSI 出生的儿童和 1008 名经射出精液后行 ICSI 出生的儿童。比较三组的死胎率、围产儿死亡率、胎龄、出生体重和先天性畸形发生率等数据。
PESA 和 TESA 组儿童的死胎率、围产儿死亡率、婴儿死亡率、胎龄、早产儿发生率和畸形发生率与 ICSI 组儿童无差异（P＞0.05）。与对照组相比，TESA 组报告的出生缺陷略有增加，但两组间无显著差异（P＞0.05）。
与射出精液相比，经附睾或睾丸精子行 ICSI 不会导致更多的死胎或先天性畸形。
