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不同严重程度毛细支气管炎中支气管扩张剂和类固醇的过度使用:毛细支气管炎——变异性、合理性及充分性研究

Overuse of bronchodilators and steroids in bronchiolitis of different severity: bronchiolitis-study of variability, appropriateness, and adequacy.

作者信息

Ochoa Sangrador C, González de Dios J

机构信息

Service of Pediatrics, Hospital Virgen de la Concha, Zamora, Spain.

Service of Pediatrics, Hospital General Universitario de Alicante, Department of Pediatrics, Universidad Miguel Hernández, Alicante, Spain.

出版信息

Allergol Immunopathol (Madr). 2014 Jul-Aug;42(4):307-15. doi: 10.1016/j.aller.2013.02.010. Epub 2013 Jun 14.

DOI:10.1016/j.aller.2013.02.010
PMID:23769739
Abstract

BACKGROUND

In the management of acute bronchiolitis there is a generalised use of treatments that have not been shown to be useful or efficacious in clinical studies. The objective of this study was to determine the appropriateness in the treatment of acute bronchiolitis of different severity within different clinical care settings.

METHODS

This is a cross-sectional, descriptive study of 5647 cases of acute bronchiolitis in 91 Spanish hospitals and primary care centres. We classified the appropriateness of the treatments according to the recommendations of a consensus conference.

RESULTS

There was an inappropriate use of treatments in 58.3% of the cases during the acute phase and in 45.4% during the maintenance phase. There was a generalised use of inhaled beta 2 agonists, regardless of the severity of the patients (hospitalised patients 69.3%, emergency care 63.2% and ambulatory 64.1%). Adrenaline was used in 30.1% of hospitalised cases and in 80.2% of intensive care patients. Systemic corticosteroids were not only used in one-third of hospitalised patients but also in 25.8% of ambulatory cases.

CONCLUSIONS

In acute bronchiolitis in Spain there is a wide use of treatments that are not recommended by the available clinical practice guidelines. Beta 2 agonist bronchodilators and corticosteroids are widely used and maintained, regardless of the severity of the patients.

摘要

背景

在急性细支气管炎的治疗中,普遍使用的一些治疗方法在临床研究中并未显示出有效或有疗效。本研究的目的是确定在不同临床护理环境中,针对不同严重程度的急性细支气管炎治疗的适宜性。

方法

这是一项对西班牙91家医院和初级保健中心的5647例急性细支气管炎病例进行的横断面描述性研究。我们根据共识会议的建议对治疗的适宜性进行分类。

结果

急性期58.3%的病例治疗使用不当,维持期为45.4%。无论患者严重程度如何,吸入性β2激动剂都被广泛使用(住院患者69.3%,急诊63.2%,门诊64.1%)。30.1%的住院病例和80.2%的重症监护患者使用了肾上腺素。全身用皮质类固醇不仅在三分之一的住院患者中使用,在25.8%的门诊病例中也有使用。

结论

在西班牙的急性细支气管炎治疗中,广泛使用了现有临床实践指南未推荐的治疗方法。β2激动剂支气管扩张剂和皮质类固醇被广泛使用且持续使用,而不考虑患者的严重程度。

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