钠钙交换与心脏收缩。
Na/Ca exchange and contraction of the heart.
机构信息
Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
出版信息
J Mol Cell Cardiol. 2013 Aug;61:28-33. doi: 10.1016/j.yjmcc.2013.06.001. Epub 2013 Jun 12.
Abstract
Sodium-calcium exchange (NCX) is the major calcium (Ca) efflux mechanism of ventricular cardiomyocytes. Consequently the exchanger plays a critical role in the regulation of cellular Ca content and hence contractility. Reductions in Ca efflux by the exchanger, such as those produced by elevated intracellular sodium (Na) in response to cardiac glycosides, raise sarcoplasmic reticulum (SR) Ca stores. The result is an increased Ca transient and cardiac contractility. Enhanced Ca efflux activity by the exchanger, for example during heart failure, may reduce diadic cleft Ca and excitation-contraction (EC) coupling gain. This aggravates the impaired contractility associated with SR Ca ATPase dysfunction and reduced SR Ca load in failing heart muscle. Recent data from our laboratories indicate that NCX can also impact the efficiency of EC coupling and contractility independent of SR Ca load through diadic cleft priming with Ca during the upstroke of the action potential. This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes".
摘要
钠钙交换（NCX）是心室肌细胞中钙（Ca）外流的主要机制。因此，该交换器在调节细胞内 Ca 含量和收缩性方面起着关键作用。交换器的 Ca 外流减少，例如心脏糖苷类药物引起的细胞内 Na 升高所产生的 Ca 外流减少，会增加肌浆网（SR）Ca 储存。结果是 Ca 瞬间增加和心脏收缩力增强。交换器的 Ca 外流活性增强，例如在心力衰竭期间，可能会降低二联体裂孔 Ca 和兴奋-收缩（EC）偶联增益。这会加剧与 SR Ca ATP 酶功能障碍和衰竭心肌中 SR Ca 负荷减少相关的收缩功能障碍。我们实验室的最新数据表明，NCX 还可以通过动作电位上升过程中二联体裂孔中的 Ca 引发来影响 EC 偶联和收缩力的效率，而与 SR Ca 负荷无关。本文是题为“心肌细胞中的 Na（+）调节”的特刊的一部分。
相似文献
1
Na/Ca exchange and contraction of the heart.钠钙交换与心脏收缩。
J Mol Cell Cardiol. 2013 Aug;61:28-33. doi: 10.1016/j.yjmcc.2013.06.001. Epub 2013 Jun 12.
2
Cardiac sodium transport and excitation-contraction coupling.心脏钠转运与兴奋-收缩偶联。
J Mol Cell Cardiol. 2013 Aug;61:11-9. doi: 10.1016/j.yjmcc.2013.06.003. Epub 2013 Jun 14.
3
Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease.心脏钠钙交换与高效兴奋-收缩偶联：对心脏病的影响。
Adv Exp Med Biol. 2013;961:355-64. doi: 10.1007/978-1-4614-4756-6_30.
4
Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials.细胞内[Na(+)]调节动作电位期间心脏兴奋-收缩耦联中 Na(+)/Ca(2+)交换体与 L 型 Ca(2+)电流的协同作用。
Basic Res Cardiol. 2011 Nov;106(6):967-77. doi: 10.1007/s00395-011-0202-z. Epub 2011 Jul 21.
5
Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes.在动作电位期间通过钠钙交换的钙内流直接促成衰竭的人类心室肌细胞的收缩。
Cardiovasc Res. 2003 Mar 15;57(4):974-85. doi: 10.1016/s0008-6363(02)00732-0.
6
Activation of reverse Na-Ca exchanger by skeletal Na channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes.骨骼肌钠通道同工型激活反向钠钙交换增加兔心肌细胞兴奋收缩偶联效率。
Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603. doi: 10.1152/ajpheart.00545.2020. Epub 2020 Dec 4.
7
Na⁺ transport in the normal and failing heart - remember the balance.正常和衰竭心脏中的 Na⁺ 转运——记住平衡。
J Mol Cell Cardiol. 2013 Aug;61:2-10. doi: 10.1016/j.yjmcc.2013.04.011. Epub 2013 Apr 19.
8
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.钠积累促进肌浆网钙泵 2 敲除的终末期心力衰竭舒张功能障碍。
J Physiol. 2010 Feb 1;588(Pt 3):465-78. doi: 10.1113/jphysiol.2009.183517. Epub 2009 Dec 14.
9
Dynamic regulation of sodium/calcium exchange function in human heart failure.人类心力衰竭中钠/钙交换功能的动态调节
Circulation. 2003 Nov 4;108(18):2224-9. doi: 10.1161/01.CIR.0000095274.72486.94. Epub 2003 Oct 13.
10
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.正常和衰竭心脏中心肌细胞钙（Ca2+）和钠（Na+）的调节
J Pharmacol Sci. 2006;100(5):315-22. doi: 10.1254/jphs.cpj06001x. Epub 2006 Mar 18.
引用本文的文献
1
Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.细胞质质子对钠钙交换的调节会改变细胞内钙动力学以及心脏对缺血的反应。
Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2423203122. doi: 10.1073/pnas.2423203122. Epub 2025 Jul 9.
2
The effects of voltage dependence and ion-binding reaction rates on a thermodynamically constrained mathematical model of the Na/Ca exchanger.电压依赖性和离子结合反应速率对钠/钙交换器热力学约束数学模型的影响。
Sci Rep. 2025 Jul 1;15(1):21122. doi: 10.1038/s41598-025-07881-y.
3
Structural mechanisms of PIP activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.人心脏钠钙交换体NCX1中PIP激活和SEA0400抑制的结构机制
Elife. 2025 May 28;14:RP105396. doi: 10.7554/eLife.105396.
4
Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications.糖尿病心脏并发症中的代谢和线粒体功能失调
Int J Mol Sci. 2025 Mar 26;26(7):3016. doi: 10.3390/ijms26073016.
5
Structural mechanisms of PIP activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.人心脏钠钙交换体NCX1中PIP激活和SEA0400抑制的结构机制
bioRxiv. 2025 Mar 13:2024.12.05.627058. doi: 10.1101/2024.12.05.627058.
6
Potential Roles of IP Receptors and Calcium in Programmed Cell Death and Implications in Cardiovascular Diseases.钙离子通道及 IP 受体在细胞程序性死亡中的作用及其与心血管疾病的关系
Biomolecules. 2024 Oct 20;14(10):1334. doi: 10.3390/biom14101334.
7
Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen-Tawil syndrome type 1.在1型安德森-塔维尔综合征小鼠模型中，肌膜和肌浆网上的Kir2.1功能障碍会导致心律失常。
Nat Cardiovasc Res. 2022 Oct;1(10):900-917. doi: 10.1038/s44161-022-00145-2. Epub 2022 Oct 17.
8
Stress-Induced Proteasome Sub-Cellular Translocation in Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias.应激诱导的心肌细胞蛋白酶体亚细胞移位导致细胞内钙处理和心律失常改变。
Int J Mol Sci. 2024 Apr 30;25(9):4932. doi: 10.3390/ijms25094932.
9
Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.心脏功能受钠依赖型钠钙交换体 NCX1 的抑制调节。
Nat Commun. 2024 May 7;15(1):3831. doi: 10.1038/s41467-024-47850-z.
10
Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target.2型糖尿病中的心肌钙处理：一个新的治疗靶点。
J Cardiovasc Dev Dis. 2023 Dec 30;11(1):12. doi: 10.3390/jcdd11010012.
本文引用的文献
1
The topology of the cardiac Na⁺/Ca²⁺ exchanger, NCX1.心脏 Na⁺/Ca²⁺ 交换器（NCX1）的拓扑结构。
J Mol Cell Cardiol. 2013 Apr;57:68-71. doi: 10.1016/j.yjmcc.2013.01.010. Epub 2013 Jan 31.
2
Calcium signaling in cardiac mitochondria.心肌线粒体中的钙信号转导。
J Mol Cell Cardiol. 2013 May;58:125-33. doi: 10.1016/j.yjmcc.2012.12.021. Epub 2013 Jan 7.
3
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.T 管重塑和兰尼碱受体构象调节钠钙交换。
Adv Exp Med Biol. 2013;961:375-83. doi: 10.1007/978-1-4614-4756-6_32.
4
Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease.心脏钠钙交换与高效兴奋-收缩偶联：对心脏病的影响。
Adv Exp Med Biol. 2013;961:355-64. doi: 10.1007/978-1-4614-4756-6_30.
5
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger.钠离子/钙交换器的离子交换机制的结构见解。
Science. 2012 Feb 10;335(6069):686-90. doi: 10.1126/science.1215759.
6
Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.心力衰竭时心肌细胞的亚细胞结构和功能受损，通过心脏再同步治疗得到恢复。
Circ Res. 2012 Feb 17;110(4):588-97. doi: 10.1161/CIRCRESAHA.111.257428. Epub 2012 Jan 17.
7
Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers.钙离子依赖的钠钙交换体二聚体的结构重排。
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1699-704. doi: 10.1073/pnas.1016114108. Epub 2011 Jan 5.
8
Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development.在兔心肌细胞发育过程中电压门控 Na+通道与 Na+/Ca2+交换体的共定位。
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H300-11. doi: 10.1152/ajpheart.00798.2010. Epub 2010 Oct 22.
9
Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels.钠离子电流对于兔心室肌细胞有效的兴奋-收缩耦联是必需的：神经元钠离子通道的一种可能贡献。
J Physiol. 2010 Nov 1;588(Pt 21):4249-60. doi: 10.1113/jphysiol.2010.194688.
10
Myocardial function with reduced expression of the sodium-calcium exchanger.心肌功能与钠钙交换体表达减少。
J Card Fail. 2010 Sep;16(9):786-96. doi: 10.1016/j.cardfail.2010.03.012. Epub 2010 May 14.
Zotero 插件