基于杂原子导向策略的离散二硫环macrocycle 化合物的合成。
Pnictogen-directed synthesis of discrete disulfide macrocycles.
机构信息
University of Oregon and Materials Science Institute, Eugene, Oregon 97403-1253, USA.
出版信息
Chem Commun (Camb). 2013 Jul 28;49(59):6599-601. doi: 10.1039/c3cc43524e.
PMID:23770675
Abstract
Cyclic disulfide macrocycles were rapidly synthesized cleanly and selectively from rigid dithiols via oxidation with iodine when activated by pnictogen additives (As and Sb). Macrocycles were confirmed by (1)H-NMR spectroscopy and X-ray crystallography. A p-xylyl-based disulfide trimer and tetramer crystallized in hollow, stacked columns stabilized by intermolecular, sulfur···sulfur close contacts.
摘要
环状二硫环macrocycles 通过氧化反应与碘迅速合成，在磷添加剂（As 和 Sb）的激活下，从刚性二硫醇中干净、选择性地合成。macrocycles 通过（1）H-NMR 光谱和 X 射线晶体学得到证实。基于对二甲苯的二硫三聚物和四聚物在空心、堆叠的柱中结晶，这些柱由分子间的硫···硫近距离接触稳定。
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