Service d'Histologie-Embryologie-Cytogénétique-Biologie de la Reproduction-CECOS, Hôpital Jean Verdier (AP-HP), HUPSSD, Bondy, France.
Asian J Androl. 2013 Sep;15(5):626-9. doi: 10.1038/aja.2013.10. Epub 2013 Jun 17.
Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index (BMI) and sperm-zona pellucida binding ability assessed according to the zona binding (ZB) test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization (IVF) ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated.
生活方式因素，如体重和营养状况，可能会影响男性生育能力，包括精子受精能力。本回顾性研究的目的是评估体重指数（BMI）与精子透明带结合能力之间的关系，根据透明带结合（ZB）试验评估，该试验已被描述为预测体外受精（IVF）能力的相关诊断工具。共纳入 306 名因原发性特发性或轻度男性因素不育而被诊断为不育的夫妇的男性患者。评估了 BMI 与根据 ZB 试验指数评估的精液参数之间的相关性，以及在 BMI 类别中阳性和阴性试验的频率。在这个选择的人群中，BMI 与根据精子穿透透明带的能力评估的常规精液参数或精子质量无关。先前描述的男性肥胖症病例中 IVF 程序不良结局可能是由于其他精子缺陷，如精子获能或顶体反应的改变。应进一步评估男性 BMI 与 IVF 过程中的生物学结果（如受精率）之间的联系。
