Gurzu Simona, Szentirmay Z, Jung I
Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania.
Rom J Morphol Embryol. 2013;54(2):241-5.
Despite thousands of studies about colorectal cancer (CRC) as much as extensively usage of prognostic antibodies÷genes and clinical trials that include the newest targeted drugs, this tumor still remains in the top of both incidence and cancer-related mortality. In this review, we intended to correlate our experience in field of colorectal cancer with the literature data and to present our vision about the prognostic and predictive role of some of the most used molecular and immunohistochemical examinations in the field. The prognostic and predictive values of parameters such as microsatellite instability, angiogenesis, Maspin gene/protein, K-ras and BRAF mutations are discussed in relationship to the classical antibodies such as Keratin 7/20, p53 or HER2. At the end, we correlated these informations and tried to realize a molecular classification of colorectal cancer, similar to breast carcinomas, in order to establish targeted groups of patients for targeted therapy.
尽管针对结直肠癌（CRC）进行了数千项研究，广泛使用了预后抗体、基因以及包含最新靶向药物的临床试验，但这种肿瘤在发病率和癌症相关死亡率方面仍名列前茅。在本综述中，我们旨在将我们在结直肠癌领域的经验与文献数据相关联，并阐述我们对该领域一些最常用分子和免疫组化检查的预后和预测作用的看法。讨论了微卫星不稳定性、血管生成、Maspin基因/蛋白、K-ras和BRAF突变等参数与角蛋白7/20、p53或HER2等经典抗体相关的预后和预测价值。最后，我们将这些信息进行关联，并试图实现类似于乳腺癌的结直肠癌分子分类，以便为靶向治疗确定目标患者群体。
