Awad Ahmed J, Forbes Jonathan A, Jermakowicz Walter, Eli Ilyas M, Blumenkopf Bennett, Konrad Peter
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Surg Neurol Int. 2013 May 17;4:64. doi: 10.4103/2152-7806.112182. Print 2013.
The authors sought to assess long-term efficacy, surgical morbidity, and postoperative quality of life in patients who have undergone dorsal root entry zone (DREZ) lesioning.
We utilized the electronic chart system at our institution to identify patients who underwent DREZ lesioning since 1986. Of the patients that were able to be identified, 19 (12 males and 7 females) patients were able to be contacted at time of data collection. The mean age was 47 years (ranging from 23 to 70 years) with average preoperative pain duration of 12.5 years and average follow-up of 4.9 years.
Of the 19 patients we were able to contact, 7 (37%) patients experienced "excellent" postoperative (complete) pain relief with another 6 (32%) reporting "good" improvement. Three (16%) patients reported "mild" pain relief, while three (16%) patients reported poor results. Sixteen patients (84%) stated they would undergo DREZ lesioning again, if given a choice. Two patients (11%) had objective evidence of a new, mild motor deficit postoperatively. More than half of the patients, who answered, reported "good" quality of life. Two-sample unequal variance t-test showed no statistically significant difference in pain improvement between brachial plexus avulsion and end-zone spinal cord injury pain.
With appropriate patient selection, DREZ lesioning is an efficacious and durable procedure that can be performed with low morbidity and good patient outcomes.
作者试图评估接受背根入髓区(DREZ)毁损术患者的长期疗效、手术并发症及术后生活质量。
我们利用本机构的电子病历系统,识别自1986年以来接受DREZ毁损术的患者。在能够识别的患者中,19例(12例男性和7例女性)患者在数据收集时能够取得联系。平均年龄为47岁(范围从23岁至70岁),术前平均疼痛持续时间为12.5年,平均随访时间为4.9年。
在我们能够联系到的19例患者中,7例(37%)患者术后疼痛得到“极佳”(完全)缓解,另外6例(32%)报告有“良好”改善。3例(16%)患者报告有“轻度”疼痛缓解,而3例(16%)患者报告效果不佳。16例患者(84%)表示,如果可以选择,他们会再次接受DREZ毁损术。2例患者(11%)术后有新的轻度运动功能障碍的客观证据。超过一半做出回答的患者报告生活质量“良好”。两样本异方差t检验显示,臂丛神经撕脱伤和终末区脊髓损伤疼痛在疼痛改善方面无统计学显著差异。
通过适当选择患者,DREZ毁损术是一种有效且持久的手术,可在低并发症发生率和良好患者预后的情况下进行。