通过铜介导的α,β-不饱和羧酸与烷基酮的环化反应合成多取代呋喃。
Synthesis of polysubstituted furans via copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids.
机构信息
Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, P. R. China.
出版信息
Org Lett. 2013 Jul 5;15(13):3206-9. doi: 10.1021/ol400912v. Epub 2013 Jun 17.
PMID:23772562
Abstract
A novel copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids has been accomplished. This reaction provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.
摘要
一种新型的铜介导的烷基酮与α,β-不饱和羧酸的环化反应已经完成。该反应为从简单的化学试剂合成 2,3,5-三取代呋喃提供了一种简便、区域定义明确的方法。
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