Pasqualetti P, Colantonio D, Casale R, Acitelli P, Natali G
Dipartimento di Medicina Interna, Università degli Studi di L'Aquila.
Minerva Med. 1990 May;81(5):391-8.
The aim of the study was to verify if sudden cardiac death presents a circadian, circaseptan, and circannual periodicity in its incidence. For the study of distribution of sudden cardiac death by hour of the day, the day of the week, and month of the year, 269 cases (161 males and 108 females), that occurred during the years 1970 through 1987 were considered. Sudden cardiac death, that is, death within 1 hour of onset of symptoms, occurs with greater frequency in the morning hours, on the days from Saturday to Monday, and in the months from October to January. The rhythmometric analysis by "single cosinor" demonstrates significant (p less than 0.05) rhythms, with acrophases at 5:00 a.m., on Monday, and in November. No significant differences (p more than 0.05) were found between male and female groups. These data suggest that sudden cardiac death is an event with high "chronorisk" that is a phenomenon with a greater probability of occurring in a definite period of time. The periodicity in the incidence of sudden cardiac death may be due to relationships between exogenous factors and endogenous biological rhythms.
该研究的目的是验证心源性猝死在发病率上是否呈现昼夜、一周和一年的周期性。为了研究心源性猝死按一天中的小时、一周中的日期和一年中的月份的分布情况，我们考虑了1970年至1987年期间发生的269例病例（161例男性和108例女性）。心源性猝死，即症状发作后1小时内死亡，在上午时段、从周六到周一以及从10月到1月的月份中发生频率更高。通过“单余弦分析”进行的节律分析显示出显著（p小于0.05）的节律，其高峰相位分别在上午5点、周一和11月。在男性和女性组之间未发现显著差异（p大于0.05）。这些数据表明，心源性猝死是一个具有高“时辰风险”的事件，即在特定时间段内更有可能发生的一种现象。心源性猝死发病率的周期性可能是由于外源性因素与内源性生物节律之间的关系。
