Blanchard Elodie, Tunon de Lara Manuel
Service des Maladies Respiratoires, Hôpital Haut Lévêque, Pessac, France.
Therapie. 2013 Mar-Apr;68(2):85-91. doi: 10.2515/therapie/2013019. Epub 2013 Jun 18.
Pholcodine is an opioid that has been widely used worldwide since 1950 for the treatment of non-productive cough in children and adults. The results of early preclinical studies but also those of recent clinical trials have shown the antitussive efficacy of pholcodine to be superior to that of codeine, of longer duration, and with an equivalent or safer toxicity profile. Also, there is no risk of addiction. Concern had been raised over a possible cross-sensitisation with neuromuscular blocking agents. While a recent assessment of the available data by the European Medicines Agency (EMA) has confirmed the favourable risk-benefit ratio of pholcodine, further studies are needed to clear this point.
福尔可定是一种阿片类药物，自1950年以来在全球广泛用于治疗儿童和成人的干咳。早期临床前研究以及近期临床试验的结果均表明，福尔可定的镇咳疗效优于可待因，作用持续时间更长，且毒性特征相当或更安全。此外，不存在成瘾风险。曾有人担心福尔可定与神经肌肉阻滞剂之间可能存在交叉致敏作用。虽然欧洲药品管理局（EMA）最近对现有数据的评估证实了福尔可定有利的风险效益比，但仍需要进一步研究来澄清这一点。
