米卡芬净与氟康唑预防早产儿真菌感染的比较
Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants.
作者信息
Maede Yoshinobu, Ibara Satoshi, Nagasaki Hiraku, Inoue Takeshi, Tokuhisa Takuya, Torikai Motofumi, Ishihara Chie, Matsui Takako, Kodaira Yuichi
机构信息
Department of Neonatology, Perinatal Medical Center, Kagoshima City Hospital, Kagoshima, Japan.
出版信息
Pediatr Int. 2013 Dec;55(6):727-30. doi: 10.1111/ped.12157. Epub 2013 Aug 21.
BACKGROUND
We conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000 g.
METHODS
With a combination of enteral administration of miconazole (6 mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5 mg/kg/day and 3 mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth.
RESULTS
The prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group.
CONCLUSION
MCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.
背景
我们进行了一项比较临床研究，以评估米卡芬净（MCFG）和氟康唑（FLCZ）对孕周小于26周、体重小于1000克的极低出生体重儿真菌感染发生率的预防效果。
方法
联合肠内给予咪康唑（6毫克/千克/天），FLCZ和MCFG分别以5毫克/千克/天和3毫克/千克/天的剂量静脉给药。当在出生后的前21天内发现真菌感染时，预防被判定为失败。
结果
FLCZ组18例中有7例（39%）预防成功，MCFG组21例中有15例（71%）预防成功，表明后一组的成功率显著更高。
结论
在预防极低出生体重儿真菌感染方面，MCFG优于FLCZ。
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