Ashkenazi-Hoffnung Liat, Rosenberg Danziger Chen
Department of Day Hospitalization and Pediatric Infectious Diseases Unit, Schneider Children's Medical Center, Petach Tikva 4920235, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel.
J Fungi (Basel). 2023 Jan 28;9(2):176. doi: 10.3390/jof9020176.
During the past decade, emerged across the world, causing nosocomial outbreaks in both pediatric and adult populations, particularly in intensive care settings. We reviewed the epidemiological trends and the clinical and microbiological characteristics of infection, focusing on the pediatric population. The review is based on 22 studies, which included about 250 pediatric patients with infection, across multiple countries; neonates and premature babies were the predominant pediatric patient group affected. The most common type of infection reported was bloodstream infection, which was associated with exceptionally high mortality rates. Antifungal treatment varied widely between the patients; this signifies a serious knowledge gap that should be addressed in future research. Advances in molecular diagnostic methods for rapid and accurate identification and for detection of resistance may prove especially valuable in future outbreak situations, as well as the development of investigational antifungals. However, the new reality of a highly resistant and difficult-to-treat pathogen calls for preparedness of all aspects of patient care. This spans from laboratory readiness, to raising awareness among epidemiologists and clinicians for global collaborative efforts to improve patient care and limit the spread of .
在过去十年中，[某种病菌]在全球出现，在儿科和成人人群中引发医院感染暴发，尤其是在重症监护环境中。我们回顾了[该病菌]感染的流行病学趋势以及临床和微生物学特征，重点关注儿科人群。该综述基于22项研究，这些研究涵盖多个国家的约250名患有[该病菌]感染的儿科患者；新生儿和早产儿是受影响的主要儿科患者群体。报告的最常见感染类型是血流感染，其死亡率极高。患者之间的抗真菌治疗差异很大；这表明存在严重的知识差距，应在未来研究中加以解决。分子诊断方法在快速准确识别和耐药性检测方面的进展可能在未来疫情暴发情况下特别有价值，以及研究性抗真菌药物的开发。然而，面对一种高度耐药且难以治疗的病原体这一新现实，需要在患者护理的各个方面做好准备。这涵盖从实验室准备，到提高流行病学家和临床医生对全球合作努力的认识，以改善患者护理并限制[该病菌]的传播。
