Hsieh Chang-Hsun, Hung Yi-Jen, Pei Dee, Kuo Shi-Wen, Lin Eugene
Division of Endocrinology and Metabolism, Tri-Service General Hospital, Taipei.
Appl Clin Genet. 2010 Mar 16;3:17-22. doi: 10.2147/tacg.s8583. Print 2010.
Nowadays diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). Recent studies have demonstrated that the myosin, heavy chain 9, non-muscle (MYH9) gene is associated with ESRD in African Americans. In this study, we tested the hypothesis that a common single nucleotide polymorphism rs16996677 in the MYH9 gene may contribute to the etiology of DN in type 2 diabetes (T2D) in a Taiwanese population with T2D. There were 180 T2D patients diagnosed with DN and 178 age- and sex-similar T2D without DN controls. Single locus analyses showed no significant main effects of MYH9 rs16996677 on the risk of DN in T2D. The results suggest that the rs16996677 SNP in MYH9 may not contribute to the risk of DN in T2D in Taiwanese T2D patients.
如今，糖尿病肾病（DN）是终末期肾病（ESRD）最常见的病因。最近的研究表明，非肌肉型肌球蛋白重链9（MYH9）基因与非裔美国人的终末期肾病有关。在本研究中，我们检验了一个假设，即MYH9基因中常见的单核苷酸多态性rs16996677可能在台湾2型糖尿病（T2D）人群中对DN的病因有影响。有180名被诊断患有DN的T2D患者和178名年龄及性别匹配的无DN的T2D患者作为对照。单基因座分析显示，MYH9 rs16996677对T2D患者发生DN的风险没有显著的主要影响。结果表明，MYH9基因中的rs16996677单核苷酸多态性可能对台湾T2D患者发生DN的风险没有影响。
