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Int J Appl Basic Med Res. 2011 Jul;1(2):97-103. doi: 10.4103/2229-516X.91153.
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Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.胰高血糖素样肽-1和艾塞那肽-4可刺激经链脲佐菌素处理的新生大鼠的β细胞新生，从而使成年期的葡萄糖稳态持续改善。
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本文引用的文献

1
Review: pancreatic beta-cell neogenesis revisited.综述：重新审视胰腺β细胞新生
Exp Diabesity Res. 2004 Apr-Jun;5(2):111-21. doi: 10.1080/15438600490455079.
2
Studies on the diabetogenic action of streptozotocin (NSC-37917).链脲佐菌素（NSC - 37917）致糖尿病作用的研究。
Cancer Chemother Rep. 1963 May;29:91-8.
3
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.胰高血糖素样肽-1和艾塞那肽-4可刺激经链脲佐菌素处理的新生大鼠的β细胞新生，从而使成年期的葡萄糖稳态持续改善。
Diabetes. 2001 Jul;50(7):1562-70. doi: 10.2337/diabetes.50.7.1562.
4
beta-cell turnover: its assessment and implications.β细胞更新：其评估及意义
Diabetes. 2001 Feb;50 Suppl 1:S20-4. doi: 10.2337/diabetes.50.2007.s20.
5
Insulin-like effect of pinitol.松醇的胰岛素样作用。
Br J Pharmacol. 2000 Aug;130(8):1944-8. doi: 10.1038/sj.bjp.0703523.
6
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.促胰岛素分泌的胰高血糖素样肽-1激动剂刺激同源域蛋白IDX-1的表达并增加小鼠胰腺胰岛大小。
Diabetes. 2000 May;49(5):741-8. doi: 10.2337/diabetes.49.5.741.
7
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.艾塞那肽-4可刺激β细胞复制和新生，从而增加糖尿病大鼠的β细胞量并改善其糖耐量。
Diabetes. 1999 Dec;48(12):2270-6. doi: 10.2337/diabetes.48.12.2270.
8
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.胰高血糖素样肽-1促进DNA合成，激活磷脂酰肌醇3激酶，并增加β（INS-1）细胞中转录因子胰腺十二指肠同源盒基因1（PDX-1）的DNA结合活性。
Diabetologia. 1999 Jul;42(7):856-64. doi: 10.1007/s001250051238.
9
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome.D-手性肌醇对多囊卵巢综合征的排卵及代谢影响
N Engl J Med. 1999 Apr 29;340(17):1314-20. doi: 10.1056/NEJM199904293401703.
10
Initiation of increased pancreatic islet growth in young normoglycemic mice (Umeå +/?).在年轻的血糖正常小鼠（于默奥 +/?）中启动胰岛生长增加。
Endocrinology. 1999 Feb;140(2):778-83. doi: 10.1210/endo.140.2.6514.

提出的实验模型，旨在推断玫瑰银合欢的β细胞新生活性的药理学证据及其降血糖活性评估。

Experimental model proposed to deduce pharmacological evidence of the beta-cell neogenesis activity of Argyrolobium roseum vis-a-vis an evaluation of its hypoglycemic activity.

作者信息

Gupta Op, Malhotra Pavan, Kudyar Surbhi, Singh Aneeta, Gupta Geetika

机构信息

Department of Pharmacology and Therapeutics, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, India.

出版信息

Int J Appl Basic Med Res. 2011 Jul;1(2):97-103. doi: 10.4103/2229-516X.91153.

DOI:10.4103/2229-516X.91153
PMID:23776786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657975/
Abstract

BACKGROUND

Argyrolobium roseum is described in texts for its botanical aspects with no mention of its therapeutic uses. Recently, a solvent fraction of this plant has been reported to possess insulin secretagogue activity.

OBJECTIVE

Primary objective of the study was to evaluate the hypoglycemic activity of different fractions of Argyrolobium roseum plant. Secondary objective was to devise a model for detecting its beta-cell neogenesis activity.

MATERIALS AND METHODS

Alcoholic fraction (AR) was studied in fasting, glucose-loaded and streptozotocin (STZ)-treated hyperglycemic rats. For deducing beta-cell neogenesis activity, a sub-lethal dose of STZ, causing delayed death in the animals, was administered.

RESULTS

AR in a dose of 200 mg/kg showed hypoglycemic activity in fasting and STZ-treated rats. With sub-lethal dose of STZ, recovery from hyperglycemia was seen.

CONCLUSION

AR of Argyrolobium roseum possesses hypoglycemic and a possible beta-cell neogenesis activity. Further studies are required to confirm its beta-cell neogenesis potential by cytological methods and to establish its role in the treatment of type 2 diabetes.

摘要

背景

玫瑰银叶豆在植物学文献中有记载，但未提及其治疗用途。最近，据报道该植物的一种溶剂提取物具有胰岛素促分泌活性。

目的

本研究的主要目的是评估玫瑰银叶豆不同提取物的降血糖活性。次要目的是设计一种检测其β细胞新生活性的模型。

材料与方法

在禁食、葡萄糖负荷及链脲佐菌素（STZ）处理的高血糖大鼠中研究乙醇提取物（AR）。为推断β细胞新生活性，给予亚致死剂量STZ，导致动物延迟死亡。

结果

剂量为200mg/kg的AR在禁食和STZ处理的大鼠中显示出降血糖活性。给予亚致死剂量STZ后，可见高血糖得到恢复。

结论

玫瑰银叶豆的AR具有降血糖及可能的β细胞新生活性。需要进一步研究通过细胞学方法确认其β细胞新生潜能，并确定其在2型糖尿病治疗中的作用。