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本文引用的文献

1
A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus.胆汁酸螯合剂综述：2型糖尿病降血糖作用的潜在机制
Postgrad Med. 2009 May;121(3 Suppl 1):25-30. doi: 10.3810/pgm.2009.05.suppl53.290.
2
Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy.考来维仑在接受胰岛素治疗但血糖控制不佳的2型糖尿病患者中的疗效与安全性。
Arch Intern Med. 2008 Jul 28;168(14):1531-40. doi: 10.1001/archinte.168.14.1531.
3
Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy.考来维仑盐酸盐可改善磺脲类药物治疗控制不佳的2型糖尿病患者的血糖控制并降低低密度脂蛋白胆固醇水平。
Diabetes Care. 2008 Aug;31(8):1479-84. doi: 10.2337/dc08-0283. Epub 2008 May 5.
4
Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors.盐酸考来维仑：降低动脉粥样硬化性冠心病风险因素。
Vasc Health Risk Manag. 2007;3(5):733-42.
5
Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus.一项前瞻性临床试验项目的原理与设计，该项目旨在评估盐酸考来维仑对2型糖尿病患者的降糖效果。
Curr Med Res Opin. 2007 Jul;23(7):1673-84. doi: 10.1185/030079907x210525.
6
Colesevelam hydrochloride.盐酸考来维仑
Am J Health Syst Pharm. 2002 May 15;59(10):932-9. doi: 10.1093/ajhp/59.10.932.
7
Absorption of colesevelam hydrochloride in healthy volunteers.健康志愿者中盐酸考来维仑的吸收情况。
Ann Pharmacother. 2002 Mar;36(3):398-403. doi: 10.1345/aph.1A143.
8
Colesevelam hydrochloride: a novel bile acid-binding resin.盐酸考来维仑：一种新型胆汁酸结合树脂。
Ann Pharmacother. 2001 Jul-Aug;35(7-8):898-907. doi: 10.1345/aph.10263.
9
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).国家胆固醇教育计划（NCEP）成人高血胆固醇检测、评估与治疗专家小组第三次报告（成人治疗小组第三次报告）执行摘要
JAMA. 2001 May 16;285(19):2486-97. doi: 10.1001/jama.285.19.2486.
10
Drug interactions with colesevelam hydrochloride, a novel, potent lipid-lowering agent.与新型强效降脂药盐酸考来维仑的药物相互作用。
Cardiovasc Drugs Ther. 2000 Dec;14(6):681-90. doi: 10.1023/a:1007831418308.

盐酸考来维仑：2型糖尿病患者的一种新型药物。

Colesevelam hydrochloride: A novel agent in patients with type 2 diabetes.

作者信息

Sekhri Kavita, Saha Lekha

机构信息

Department of Pharmacology, Dr. HSJ Institute of Dental Sciences, Panjab University, Chandigarh, India.

出版信息

Int J Appl Basic Med Res. 2011 Jul;1(2):113-5. doi: 10.4103/2229-516X.91157.

DOI:10.4103/2229-516X.91157
PMID:23776789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657969/
Abstract

Hyperglycemia and hyperlipidemia are both risk factors for the development of various complications in patients with type 2 diabetes mellitus. Colesevelam hydrochloride is a novel agent that can improve both hypercholesterolemia and hyperglycemia in such patients. It is an orally administered bile acid sequestrant with high capacity for binding bile acids. This drug can offer potential new diabetes treatment along with other drugs.

摘要

高血糖和高血脂都是2型糖尿病患者发生各种并发症的危险因素。盐酸考来维仑是一种新型药物，可改善此类患者的高胆固醇血症和高血糖。它是一种口服的胆汁酸螯合剂，具有高容量结合胆汁酸的能力。这种药物可以与其他药物一起提供潜在的新糖尿病治疗方法。