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成人亚洲印度人群中ACE(I/D)和Apo E(Hha I)基因多态性对肥胖、脂肪量及血糖水平的协同作用:一项来自印度加尔各答的基于人群的研究

Synergistic effects of ACE (I/D) and Apo E (Hha I) gene polymorphisms on obesity, fat mass, and blood glucose level among the adult Asian Indians: A population-based study from Calcutta, India.

作者信息

Das Mithun, Pal Susil, Ghosh Arnab

机构信息

Department of Anthropology, Sree Chaitanya College, Habra, West Bengal, India.

出版信息

Indian J Endocrinol Metab. 2013 Jan;17(1):101-4. doi: 10.4103/2230-8210.107816.

Abstract

The study was aimed to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) and apolipoprotein E (Apo E) Hha I gene polymorphisms with obesity, fat mass, and blood glucose levels in Asian Indian population. A total of 350 (184 men and 166 women) adult (30 years and above) Asian Indians of Calcutta and suburb participated in the study. Anthropometric measures, fat mass, and blood glucose measures were collected. Out of 350 subjects, a sample of 139 individuals was collected randomly for genotyping (adjusted for age and sex). The ACE and Apo E genotypes were determined by agarose gel electrophoresis. It was observed that neither ACE (I/D) nor Apo E (Hha I) gene polymorphisms showed any significant association with body mass index, waist circumference, fat mass, fasting, and post meal blood glucose levels. Even synergistically (ACE + Apo E), these two polymorphisms showed no significant association with obesity, fat mass, and blood glucose level. ACE (I/D), Apo E (Hha I), as well as ACE + Apo E seem to have no significant association with obesity, fat mass, and blood glucose levels in this population.

摘要

该研究旨在确定血管紧张素转换酶(ACE)插入/缺失(I/D)和载脂蛋白E(Apo E)Hha I基因多态性与亚洲印度人群肥胖、脂肪量及血糖水平之间的关联。共有350名(184名男性和166名女性)年龄在30岁及以上的加尔各答及其郊区的成年亚洲印度人参与了该研究。收集了人体测量指标、脂肪量和血糖测量值。在350名受试者中,随机抽取了139名个体进行基因分型(根据年龄和性别进行调整)。通过琼脂糖凝胶电泳确定ACE和Apo E基因型。结果发现,ACE(I/D)和Apo E(Hha I)基因多态性均与体重指数、腰围、脂肪量、空腹及餐后血糖水平无显著关联。即使两者协同作用(ACE + Apo E),这两种多态性也与肥胖、脂肪量和血糖水平无显著关联。在该人群中,ACE(I/D)、Apo E(Hha I)以及ACE + Apo E似乎与肥胖、脂肪量和血糖水平均无显著关联。

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