Eder Piotr, Katulska Katarzyna, Lykowska-Szuber Liliana, Stawczyk-Eder Kamila, Krela-Kaźmierczak Iwona, Linke Krzysztof
Pol Arch Med Wewn. 2013;123(7-8):378-85. doi: 10.20452/pamw.1825. Epub 2013 Jun 14.
Magnetic resonance enterography (MRE) is believed to be a reliable diagnostic method in assessing the activity of small-bowel Crohn's disease (CD). However, there are no scales for quantifying MRE scores that could be used in everyday clinical practice.
The aim of the study was to construct a simple scale for assessing the activity of CD (Simple Enterographic Activity Score for Crohn's Disease - SEAS-CD) in MRE and to investigate its clinical usefulness.
We conducted a retrospective analysis of MRE findings in 122 patients with CD. Disease activity was assessed using the SEAS-CD. The reference standard was endoscopic assessment using the Simple Endoscopic Score for Crohn's Disease (SES-CD). We assessed correlations between SEAS-CD and endoscopic, clinical, and biochemical findings. We also proposed the Global Crohn's Disease Activity Score to assess total CD activity by summarizing the colonic SES-CD and SEAS-CD scores.
In the validation group (n = 62), a significant correlation between the ileal SES-CD and ileal SEAS-CD scores was noted (r = 0.72, P <0.0001). In patients with isolated small-bowel CD, there was a significant correlation between SEAS-CD and Crohn's Disease Activity Index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), albumin, and platelet count. In patients with ileocolonic CD, the Global Crohn's Disease Activity Score correlated with CDAI, CRP, ESR, Hb, and hematocrit.
SEAS-CD is a useful tool for the quantification of small-bowel CD activity assessed by MRE. The Global Crohn's Disease Activity Score may be useful in assessing the progression of lesions in patients with ileocolonic CD.
磁共振小肠造影（MRE）被认为是评估小肠克罗恩病（CD）活动度的可靠诊断方法。然而，目前尚无可用于日常临床实践的MRE评分量化标准。
本研究旨在构建一种用于评估MRE中CD活动度的简易评分标准（克罗恩病简易小肠造影活动评分 - SEAS-CD），并探讨其临床实用性。
我们对122例CD患者的MRE检查结果进行了回顾性分析。使用SEAS-CD评估疾病活动度。参考标准为采用克罗恩病简易内镜评分（SES-CD）进行内镜评估。我们评估了SEAS-CD与内镜、临床及生化检查结果之间的相关性。我们还提出了全球克罗恩病活动评分，通过汇总结肠SES-CD和SEAS-CD评分来评估CD的整体活动度。
在验证组（n = 62）中，回肠SES-CD与回肠SEAS-CD评分之间存在显著相关性（r = 0.72，P <0.0001）。在孤立性小肠CD患者中，SEAS-CD与克罗恩病活动指数（CDAI）、C反应蛋白（CRP）、红细胞沉降率（ESR）、血红蛋白（Hb）、白蛋白及血小板计数之间存在显著相关性。在回结肠型CD患者中，全球克罗恩病活动评分与CDAI、CRP、ESR、Hb及血细胞比容相关。
SEAS-CD是一种用于量化MRE评估的小肠CD活动度的有用工具。全球克罗恩病活动评分可能有助于评估回结肠型CD患者病变的进展情况。
