巴西南部的耐奥司他韦的甲型 H1N1pdm09 流感病毒。
Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil.
机构信息
Universidade Luterana do Brasil, Canoas, RS, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2013 May;108(3):392-4. doi: 10.1590/S0074-02762013000300021.
Abstract
The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
摘要
对 306 名感染患者的 A(H1N1)pdm09 流感病毒分离株的神经氨酸酶 (NA) 基因进行了分析。此前，巴西尚未报告奥司他韦耐药病毒的流行情况。临床样本采集自 2009-2011 年的南里奥格兰德州（RS），鉴定出两种神经氨酸酶抑制剂耐药突变体，一种是 2009 年的 H275Y，另一种是 2011 年的 S247N。本研究显示耐药病毒的流行率较低（0.8%），且耐药突变体在 RS 未传播。
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