Ogino K, Hobara T, Kobayashi H, Iwamoto S
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Toxicol Lett. 1990 Jul;52(2):129-33. doi: 10.1016/0378-4274(90)90146-d.
Gastric mucosal injury by chloral hydrate (CH) was investigated in the rat. Rats were injected with CH intraperitoneally or subcutaneously. After the CH injection, gastric ulcers appeared in the glandular stomach at 6 h and the ulcer index peaked in 12 h. The minimum dosage of CH to produce ulcers was 400 mg/kg intraperitoneally and 600 mg/kg subcutaneously.
研究了水合氯醛（CH）对大鼠胃黏膜的损伤。给大鼠腹腔内或皮下注射水合氯醛。注射水合氯醛后，腺胃在6小时出现胃溃疡，溃疡指数在12小时达到峰值。产生溃疡的水合氯醛最小剂量腹腔内注射为400mg/kg，皮下注射为600mg/kg。
