[使用低剂量增敏辐射治疗宫颈癌的结果]

[The results of the radiation treatment of cervical cancer using low, sensitizing doses of radiation].

作者信息

Iakimova T P, Gerinshteĭn I G, Pashchenko N S, Lozinskaia I N, Kozyreva T V, Serebriakov A M

出版信息

Vopr Onkol. 1990;36(6):678-82.

Abstract

Combined radiation treatment for cervical cancer is associated with radiation injury to the intestine, bladder, hemopoietic system and suppression of T-system, nonspecific immunity and thyroid function. Modified gamma-ray teletherapy was suggested which included low-dose (0.1 Gy) sensitizing irradiation of tumor and zones of regional dissemination prior to delivering therapeutic dose (1.9 Gy). The procedure assured lower incidence of radiation-induced reactions and complications, leukopenia and T-lymphocyte function suppression, stimulated nonspecific resistance and thyrotropic function of the pituitary, and provided normal function of the thyroid. As a result, five-year survival rate in patients with stage III cancer increased by 14%.

摘要

宫颈癌的联合放射治疗会对肠道、膀胱、造血系统造成辐射损伤，并抑制T系统、非特异性免疫和甲状腺功能。有人提出了改良的伽马射线远距离治疗法，即在给予治疗剂量（1.9 Gy）之前，对肿瘤及区域扩散区域进行低剂量（0.1 Gy）的致敏照射。该方法可确保辐射诱导反应和并发症、白细胞减少症以及T淋巴细胞功能抑制的发生率降低，刺激垂体的非特异性抵抗力和促甲状腺功能，并使甲状腺功能正常。结果，III期癌症患者的五年生存率提高了14%。