Department of Surgery, School of Medicine, Kurume University, Fukuoka, Japan.
Anticancer Res. 2013 Jul;33(7):2941-7.
In tumor cells, monocarboxylate transporter (MCT)-4 regulates the excretion of lactate produced by glycolysis from the cell. MCT4 has also been reported to be involved in tumor growth and infiltration. Similarly, vascular endothelial growth factor (VEGF) is known to be involved in the growth, infiltration, and metastasis of tumors. In this study, we clinically evaluated the relationship between MCT4 and VEGF in colorectal cancer.
A prospective study was conducted in 210 patients with colorectal cancer who underwent surgical treatment. The clinicopathological data were correlated with the expression of MCT4 and VEGF obtained from immunohistochemical analysis.
MCT4 and VEGF were expressed in tumors of 102 (49%) and 129 (61%) patients, respectively. A maximum tumor diameter of 45 mm or more (p<0.0001) and a tumor invasion depth of T1 or less (p<0.0119) were factors independently correlated with the expression of MCT4 and VEGF, respectively. The tumor size was significantly smaller (p=0.0031), and the disease was significantly less advanced (p=0.0017), in MCT4-negative/VEGF-positive than MCT4-positive/VEGF-negative cases.
We suspect that in colorectal cancer, VEGF is involved in the early stages of tumor growth and MCT4 expression appears as the tumor enlarges and contributes to its further infiltration and growth.
在肿瘤细胞中，单羧酸转运蛋白（MCT）-4 调节糖酵解产生的乳酸从细胞中的排泄。据报道，MCT4 还参与肿瘤的生长和浸润。同样，血管内皮生长因子（VEGF）已知参与肿瘤的生长、浸润和转移。在这项研究中，我们临床评估了结直肠癌中 MCT4 与 VEGF 之间的关系。
对 210 例接受手术治疗的结直肠癌患者进行了前瞻性研究。将临床病理数据与免疫组织化学分析获得的 MCT4 和 VEGF 的表达相关联。
MCT4 和 VEGF 在 102 例（49%）和 129 例（61%）患者的肿瘤中表达。肿瘤直径≥45mm（p<0.0001）和肿瘤侵犯深度 T1 或更浅（p<0.0119）是与 MCT4 和 VEGF 表达分别独立相关的因素。MCT4 阴性/VEGF 阳性病例的肿瘤大小显著较小（p=0.0031），疾病分期显著较早（p=0.0017）。
我们怀疑在结直肠癌中，VEGF 参与肿瘤生长的早期阶段，而 MCT4 的表达随着肿瘤的增大而出现，并有助于其进一步浸润和生长。
