Radke E U, Papke J, Michel G, Hübler A, Mustafa K, Martin K, Eichelroth E
Inneren Abteilung, Kreiskrankenhauses Sebnitz.
Z Gesamte Inn Med. 1990 Apr 15;45(8):214-8.
From 1978 to 1988 in 77 patients of a district hospital, 58 females and 19 males, with malignant tumours or haemoblastoses a therapy with cytostatic agents was finished. A retrospective study analyses characteristics of haematotoxic side effects of cytostatic agents, which despite usual dosage according to the valid guide-lines have appeared in this patient population. According to this the granulocytopoiesis is injured most frequently and most severely. In one third of all patients under influence of cytostatic agents the number of the segment-nuclear granulocytes in the peripheral blood decreased deeper than 0.5 Gpt/l (severe neutropenia). In toxic influences on the thrombopoiesis slight and medium degrees of severity are dominating. Lesions of the erythropoiesis are apparently more infrequent, though they are more difficult to be proved. Further characteristics in the occurrence of severe neutropenias (date, dependence on age, pharmacological aspects) are demonstrated and discussed.
1978年至1988年期间，某地区医院的77例患者（58名女性和19名男性）完成了针对恶性肿瘤或血液病的细胞毒性药物治疗。一项回顾性研究分析了细胞毒性药物血液毒性副作用的特征，这些副作用在该患者群体中出现，尽管是按照有效指南的常规剂量使用。据此，粒细胞生成最常且最严重地受到损害。在所有接受细胞毒性药物影响的患者中，三分之一外周血中节段核粒细胞数量下降超过0.5 Gpt/l（严重中性粒细胞减少症）。对血小板生成的毒性影响以轻度和中度为主。红细胞生成的损伤显然较少见，尽管更难证实。文中展示并讨论了严重中性粒细胞减少症发生的其他特征（日期、对年龄的依赖性、药理学方面）。
