Hauger R L, O'Connor K A, Yudofsky S, Meltzer H L
San Diego Veterans Administration Medical Center, La Jolla, California.
Acta Psychiatr Scand. 1990 Jun;81(6):515-7. doi: 10.1111/j.1600-0447.1990.tb05490.x.
A case of severe lithium intoxication is presented in which the function of the lithium pump was monitored, and was found to improve as the signs of lithium toxicity abated. The status of the lithium pump may provide an index of the severity of lithium intoxication. Since the lithium pump regulates the extrusion of lithium from the intracellular to the extracellular space, it is argued that the activity of the lithium pump is an index of the severity of lithium intoxication and crucial to the process of detoxification.
本文报告了一例严重锂中毒病例，对该病例的锂泵功能进行了监测，发现随着锂中毒症状的减轻，锂泵功能有所改善。锂泵的状态可能为锂中毒的严重程度提供一个指标。由于锂泵调节锂从细胞内空间向细胞外空间的排出，因此有人认为锂泵的活性是锂中毒严重程度的一个指标，并且对解毒过程至关重要。
