Sandmann M C, Gorz A M, Gracia C M, Batista R J, Seixas R R, Bittencourt P R
Unidade de Neurologia Clínica, Hospital Nossa Senhora das Graças, Curitiba, Brasil.
Arq Neuropsiquiatr. 1990 Mar;48(1):44-8. doi: 10.1590/s0004-282x1990000100007.
Between 1982 and 1988 24 women and 6 men with myasthenia gravis were included in a prospective and standardized diagnostic and therapeutic protocol. Age varied between 10 and 74 years (34 +/- 16, mean +/- standard deviation). Three patients with the ocular form were treated with pyridostigmine. Four patients with the generalized form and advanced age received steroids and/or azathioprine. Twenty-three patients with the generalized form underwent thymectomy followed by prednisone and/or azathioprine. One patient died after complex thymectomy for invasive thymoma. Another died soon after admission in myasthenic/cholinergic crisis. Two other patients had minor complications of thymectomy. Of 19 patients followed for 1-60 (mean 24) months, 11 (58%) are in remission, one of them without any medication.
1982年至1988年间，24名女性和6名男性重症肌无力患者被纳入一项前瞻性标准化诊断和治疗方案。年龄在10岁至74岁之间（平均34±16岁，均值±标准差）。3例眼肌型患者接受了吡啶斯的明治疗。4例全身型且年龄较大的患者接受了类固醇和/或硫唑嘌呤治疗。23例全身型患者接受了胸腺切除术，随后使用泼尼松和/或硫唑嘌呤。1例患者因侵袭性胸腺瘤接受复杂胸腺切除术后死亡。另1例在入院后不久因重症肌无力/胆碱能危象死亡。另外2例患者出现了胸腺切除术后的轻微并发症。在19例随访1至60个月（平均24个月）的患者中，11例（58%）病情缓解，其中1例无需任何药物治疗。
