MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Transpl Int. 2013 Dec;26(12):1149-60. doi: 10.1111/tri.12129. Epub 2013 Jun 20.
A mouse model of kidney transplantation was first described in 1973 by Skoskiewicz et al. Although the mouse model is technically difficult, it is attractive for several reasons: the mouse genome has been characterized and in many aspects is similar to man and there is a greater diversity of experimental reagents and techniques available for mouse studies than other experimental models. We reviewed the literature on all studies of mouse kidney transplantation to report the donor and recipient strain combinations that have been investigated and the resultant survival and histological outcomes. Some models of kidney transplantation have used the transplanted kidney as a life-supporting organ, however, in many studies the recipient mouse's native kidney has been left in situ. Several different combinations of inbred mouse strains have been reported, with varying degrees of injury, survival or tolerance because of haplotype differences. This model has been exceptionally useful as an investigational tool to understand multiple aspects of transplantation including acute rejection, cellular and humoral rejection mechanisms and their treatment. Furthermore, this model has been used to investigate disease mechanisms beyond transplant rejection including intrinsic renal disease and infection-associated pathology.
1973 年，Skoskiewicz 等人首次描述了一种肾脏移植的小鼠模型。尽管该小鼠模型在技术上具有一定难度，但它具有以下几个吸引人的特点：小鼠基因组已经被阐明，在许多方面与人类相似，并且有更多的实验试剂和技术可用于小鼠研究，而其他实验模型则相对较少。我们对所有关于小鼠肾脏移植的研究进行了综述，以报告已经研究过的供体和受体品系组合，以及由此产生的生存和组织学结果。一些肾脏移植模型将移植的肾脏作为维持生命的器官，然而，在许多研究中，受体小鼠的原生肾脏仍保留在原位。已经报道了几种不同的近交系小鼠品系组合，由于单倍型差异，这些组合导致了不同程度的损伤、存活率或耐受性。这种模型作为一种研究工具非常有用，可以帮助我们理解移植的多个方面，包括急性排斥、细胞和体液排斥机制及其治疗。此外，该模型还被用于研究移植排斥以外的疾病机制，包括内在肾脏疾病和感染相关的病理。
