Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK.
Br J Haematol. 2013 Aug;162(4):509-16. doi: 10.1111/bjh.12425. Epub 2013 Jun 21.
The 5-year relative survival of adults diagnosed with acute myeloid leukaemia (AML) was less than 10% during the 1970s and 1980s in England. This population-based study estimated the 5-year relative survival and 'cure' for 48 380 adult patients diagnosed with AML in England during 1971-2006. Relative survival and cure mixture models were used to produce estimates of 5-year relative survival and the percentage 'cured'. 'Cure' was defined as the proportion of a group of survivors for whom there is no excess mortality compared with the general population. The 5-year relative survival and the percentage 'cured' increased for patients aged under 70 years at diagnosis during 1971-2006, but advancing age was associated with poorer outcome. During the study period a dramatic increase in 5-year relative survival occurred in those aged 15-24 years, from 7% to 53%. The percentage 'cured' was less than 10% for all ages in 1975, but increased to 45% for those aged 15-24 years in 2000. Cure could not be estimated for patients over 70 years, because survival was consistently low (<5%). The long-term outcome of patients with AML has improved substantially, particularly in younger patients. The potential exists for further increasing levels of 'cure'.
在 20 世纪 70 年代和 80 年代，英国诊断出的急性髓系白血病（AML）成人患者的 5 年相对生存率不到 10%。本项基于人群的研究估计了 1971-2006 年期间在英格兰诊断出的 48380 名 AML 成年患者的 5 年相对生存率和“治愈”率。使用相对生存率和治愈率混合模型来估计 5 年相对生存率和“治愈”的百分比。“治愈”定义为与一般人群相比，无超额死亡率的幸存者比例。在 1971-2006 年期间，年龄在 70 岁以下的患者的 5 年相对生存率和“治愈”率增加，但年龄的增长与较差的结果相关。在研究期间，年龄在 15-24 岁的患者 5 年相对生存率从 1975 年的 7%急剧增加到 53%。1975 年所有年龄段的“治愈”率都不到 10%，但在 2000 年，年龄在 15-24 岁的患者的“治愈”率增加到 45%。对于 70 岁以上的患者，无法估计治愈率，因为生存始终很低（<5%）。AML 患者的长期预后有了显著改善，尤其是在年轻患者中。进一步提高“治愈”率的潜力是存在的。
