印度药用植物复方制剂（PHF）的抗溃疡活性。
Antiulcer activity of a polyherbal formulation (PHF) from Indian medicinal plants.
机构信息
Department of Pharmacology, Bioneeds Pre Clinical Services, Bangalore, India.
出版信息
Chin J Nat Med. 2013 Mar;11(2):145-8. doi: 10.1016/S1875-5364(13)60041-2.
AIM
The present study was aimed at evaluating the antiulcer activity of the polyherbal formulation (PHF) containing the leaf extracts of Moringa oleifera, Raphinus sativus, and Amaranthus tricolor in rats.
METHODS
The antiulcer activity of the polyherbal formulation (PHF) was evaluated using different models of gastric ulcers: ethanol-induced, indomethacin-induced and ischemia reperfusion-induced gastric ulcers. Efficacy was assessed by determining the ulcer index.
RESULTS
Administration of the polyherbal formulation (150 mg·kg(-1), p.o.) offered significant protection against indomethacin-induced, ethanol-induced, and ischemic reperfusion-induced ulcer models when compared to the control group.
CONCLUSION
PHF, containing leaf extracts of Moringa oleifera, Raphinus sativus, and Amaranthus tricolor, was found to possess antiulcer properties in three experimental animal models of gastric ulcers, and these findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity.
目的
本研究旨在评估含有辣木叶、萝卜和苋菜叶提取物的复方草药（PHF）在大鼠中的抗溃疡活性。
方法
采用乙醇诱导、吲哚美辛诱导和缺血再灌注诱导的胃溃疡模型评价复方草药（PHF）的抗溃疡活性。通过测定溃疡指数来评估疗效。
结果
与对照组相比，复方草药（150mg·kg(-1)，po）给药对吲哚美辛诱导、乙醇诱导和缺血再灌注诱导的胃溃疡模型具有显著的保护作用。
结论
含有辣木叶、萝卜和苋菜叶提取物的 PHF 在三种实验性胃溃疡动物模型中具有抗溃疡特性，这些发现表明其显著的胃保护活性可能与其抗氧化活性有关。
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